SCHEMBL2538499

SCHEMBL2538499

C=COC(=O)c1ccc(Cl)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.48
CES1 P23141 3/20 0.48
L3MBTL1 Q9Y468 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
ALOX15 P16050 2/20 0.46
TSHR P16473 1/20 0.46
ALDH1A1 P00352 2/20 0.46
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
GSK3B P49841 2/20 0.42
SRD5A2 P31213 1/20 0.42
MAPK1 P28482 1/20 0.42
HPGD P15428 1/20 0.41
GAA P10253 1/20 0.41
KDM4E B2RXH2 1/20 0.41
LMNA P02545 1/20 0.41
MAPT P10636 1/20 0.41
KMT2A Q03164 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL27259678 0.93 ALOX15 (0.45) CES2CES1L3MBTL1SMN1; SMN2NPC1
SCHEMBL295796 0.89 ALDH1A1 (0.40) TSHRALDH1A1CA1CA2LMNA
SCHEMBL28944014 0.87 ALDH1A1 (0.39) TSHRALDH1A1CA1CA2LMNA
SCHEMBL19506902 0.83 PDCD1 (0.41) SMN1; SMN2ALDH1A1CA1CA2KDM4E
SCHEMBL787166 0.81 TSHR (0.52) CES2CES1L3MBTL1SMN1; SMN2ALOX15
Acetic Acid SCHEMBL27275952 0.81 TSHR (0.40) L3MBTL1SMN1; SMN2RAB9ATSHRALDH1A1
SCHEMBL689989 0.81 CA1 (0.54) SMN1; SMN2TSHRALDH1A1CA1CA2
SCHEMBL1377357 0.81 CES2 (0.50) CES2CES1L3MBTL1SMN1; SMN2NPC1
SCHEMBL24858702 0.79 CA1 (0.57) L3MBTL1NPC1RAB9ATSHRALDH1A1
SCHEMBL19506924 0.79 PARP10 (0.48) SMN1; SMN2NPC1RAB9ATSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5338803-A Chlorinated polyethylene graft polymerized with unsaturated carboxylic acid ester monomer, a monovinyl aromatic monomer or mixtures THE DOW CHEMICAL COMPANY (US) 1994-08-16 US claimed
US-9856414-B2 Compositions, systems and methods of making coated additive components DOBER CHEMICAL CORP. (US) 2018-01-02 US disclosed
US-20140364345-A1 Compositions, Systems and Methods of Making Coated Additive Components DOBER CHEMICAL CORP. 2014-12-11 US disclosed
US-20130255951-A1 Compositions, Systems and Methods for Releasing Additive Components DOBER CHEMICAL CORPORATION (US) 2013-10-03 US disclosed
CN-1501836-B Controlled release cooling additive composition DOBER CHEMICAL CORP 2012-10-10 CN disclosed
CN-101312937-B Process for preparing vinyl carboxylates BASF SE 2012-07-04 CN disclosed
US-8044233-B2 Process for preparing vinyl carboxylates BASF AKTIENGESELLSCHAFT (DE) 2011-10-25 US disclosed
US-7524434-B2 Controlled release cooling additive composition DOBER CHEMICAL CORPORATION (US) 2009-04-28 US disclosed
US-20080308765-A1 Process for Preparing Vinyl Carboxylates BASF SE (DE) 2008-12-18 US disclosed
CN-101312937-A Process for preparing vinyl carboxylates BASF AG (DE) 2008-11-26 CN disclosed
US-4003962-A Method of preparing an easy processing polyvinyl halide by an in-process reaction HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1977-01-18 US disclosed
US-4001156-A Method of producing epoxy group-containing, quaternary ammonium salt-containing resins PPG INDUSTRIES, INC. (US) 1977-01-04 US disclosed
US-3975346-A ELECTRO-DEPOSITION PPG INDUSTRIES, INC. (US) 1976-08-17 US disclosed
US-3970612-A BULK POLYMERIZATION HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1976-07-20 US disclosed
US-3959106-A EPOXY COMPOUNDS; SULFIDES PPG INDUSTRIES, INC. (US) 1976-05-25 US disclosed
US-3956422-A MOLDING MATERIALS HOOKER CHEMICALS & PLASTICS CORPORATION (US) 1976-05-11 US disclosed
US-3939051-A Process for electrodeposition of cationic thermosetting compositions PPG INDUSTRIES, INC. (US) 1976-02-17 US disclosed
US-3937679-A COATINGS, AMMONIUM, SULFONIUM, OR PHOSPHONIUM ACID SALT, AMINE-ALDEHYDE CONDENSATE, AND A METHYOL PHENOL ETHER PPG INDUSTRIES, INC. (US) 1976-02-10 US disclosed
US-3936405-A CATIONIC POLYMER PPG INDUSTRIES, INC. (US) 1976-02-03 US disclosed
US-3933940-A Mercaptan blocked thermosetting copolymers PPG INDUSTRIES, INC. (US) 1976-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080308765-A1 Process for Preparing Vinyl Carboxylates MVD, MMAB, CRBN CES2 1880/4885CES1 2667/4885L3MBTL1 4032/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.