SCHEMBL25398686

SCHEMBL25398686

O=C(O)C1(Cc2ccccc2)CC(COCc2cccc(Cl)c2)=NO1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.41
EGLN1 Q9GZT9 1/20 0.41
RXRA P19793 1/20 0.39
RXRB P28702 1/20 0.39
RXRG P48443 1/20 0.39
MRGPRX4 Q96LA9 1/20 0.38
GRM5 P41594 1/20 0.38
NR4A2 P43354 1/20 0.38
ALKBH1 Q13686 1/20 0.38
TACR1 P25103 2/20 0.37
MAOA P21397 2/20 0.37
MAOB P27338 2/20 0.37
GRIN2B Q13224 1/20 0.37
FFAR4 Q5NUL3 1/20 0.36
GRM2 Q14416 1/20 0.36
GRM3 Q14832 1/20 0.36
HSD11B1 P28845 1/20 0.35
THRA P10827 1/20 0.35
THRB P10828 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25398914 0.90 EGLN1 (0.39) HCAR2EGLN1RXRARXRBRXRG
SCHEMBL25399422 0.89 TSHR (0.40) HCAR2EGLN1GRM5
SCHEMBL25400425 0.88 EGLN1 (0.41) EGLN1MAOBGRIN2BFFAR4THRA
SCHEMBL25398131 0.86 RXRA (0.46) RXRARXRBRXRGMRGPRX4NR4A2
SCHEMBL25400362 0.85 EGLN1 (0.43) EGLN1MRGPRX4ALKBH1MAOAMAOB
SCHEMBL25398873 0.85 ALKBH1 (0.41) GRM5ALKBH1MAOBFFAR4
SCHEMBL25400244 0.82 PSMB5 (0.42) EGLN1MAOB
SCHEMBL25399913 0.82 MAPK1 (0.37) EGLN1
SCHEMBL25398297 0.80 KDM4E (0.41) EGLN1GRIN2B
SCHEMBL29846130 0.80 FFAR1 (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570675-B2 Boronic acid compounds LG CHEM, LTD. (KR) 2026-03-10 US disclosed
US-20240101579-A1 BORONIC ACID COMPOUNDS LG CHEM, LTD. (KR) 2024-03-28 US disclosed
EP-4242213-A1 BORONIC ACID COMPOUND Lg Chem, Ltd. (KR) 2023-09-13 EP disclosed
WO-2022123530-A1 BORONIC ACID COMPOUND 주식회사 엘지화학 2022-06-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12570675-B2 Boronic acid compounds PSMB6, PSMB3, PSMB2 HCAR2 2042/4885EGLN1 2950/4885RXRA 769/4885
US-20240101579-A1 BORONIC ACID COMPOUNDS PSMB11, PSMB1, BACH1 HCAR2 3244/4885EGLN1 1347/4885RXRA 3782/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.