SCHEMBL25400987

SCHEMBL25400987

Cc1nocc1C(=O)NCC1=NOC(Cc2ccccc2)(C(=O)N[C@@H](CC(C)C)B(O)O)C1

nearest known ligand 0.39

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ PSMB5 P28074 19/20 0.39
▸ PSMB8 P28062 1/20 0.39
▸ PSMB1 P20618 6/20 0.37
▸ PSMB2 P49721 6/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25400991 1.00 PSMB5 (0.39) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25399263 0.88 PSMB5 (0.48) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25399267 0.88 PSMB5 (0.48) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25396509 0.87 PSMB5 (0.39) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25396506 0.87 PSMB5 (0.39) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25401708 0.86 PSMB5 (0.45) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25401712 0.86 PSMB5 (0.45) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25399864 0.86 CLPP (0.51) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25399859 0.86 CLPP (0.51) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25438514 0.85 PSMB5 (0.38) PSMB5PSMB8PSMB1PSMB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570675-B2 Boronic acid compounds LG CHEM, LTD. (KR) 2026-03-10 — — US disclosed
US-20240101579-A1 BORONIC ACID COMPOUNDS LG CHEM, LTD. (KR) 2024-03-28 — — US disclosed
EP-4242213-A1 BORONIC ACID COMPOUND Lg Chem, Ltd. (KR) 2023-09-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12570675-B2 Boronic acid compounds PSMB6, PSMB3, PSMB2 PSMB5 10/4885PSMB8 5/4885PSMB1 4/4885
US-20240101579-A1 BORONIC ACID COMPOUNDS PSMB11, PSMB1, BACH1 PSMB5 7/4885PSMB8 28/4885PSMB1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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