Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GCK | P35557 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8234824 | 0.95 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL16352667 | 0.83 | RAB9A (0.41) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL12237939 | 0.82 | GCK (0.40) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL9866203 | 0.81 | HRH1 (0.45) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL26464931 | 0.81 | ALOX5 (0.47) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL20099911 | 0.81 | ALDH1A1 (0.42) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL14554001 | 0.80 | PDE10A (0.43) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL2546751 | 0.79 | ALDH1A1 (0.56) | SMN1; SMN2NPC1RAB9AGCKHSD17B10 | |
| SCHEMBL8554211 | 0.79 | PDE10A (0.42) | SMN1; SMN2NPC1RAB9ALMNAMEN1 | |
| SCHEMBL26720549 | 0.79 | PDE10A (0.42) | SMN1; SMN2NPC1RAB9ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190811-B1 | RENIN INHIBITORS | MERCK CANADA INC (CA) | 2013-08-07 | — | — | EP | disclosed |
| US-8334308-B2 | Renin inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-12-18 | — | — | US | disclosed |
| US-20110263658-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2011-10-27 | — | — | US | disclosed |
| EP-2190811-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009023964-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263658-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | SMN1; SMN2 4699/4885NPC1 3101/4885RAB9A 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.