Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.47 |
| ▸ | LOX | P28300 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 2/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3159925 | 0.72 | — | — | |
| SCHEMBL826349 | 0.72 | LOXL2 (0.52) | LOXL2LOXSMARCA2SMARCA4NOTUM | |
| SCHEMBL19837363 | 0.72 | ADRB1 (0.40) | LOXL2LOX | |
| Hydrochloric Acid SCHEMBL3745557 | 0.71 | LOXL2 (0.53) | LOXL2LOXSMARCA2SMARCA4NOTUM | |
| SCHEMBL2642373 | 0.70 | LOXL2 (0.53) | LOXL2LOXSMARCA2SMARCA4NOTUM | |
| SCHEMBL1643559 | 0.70 | LOXL2 (0.53) | LOXL2LOXSMARCA2SMARCA4NOTUM | |
| SCHEMBL30328281 | 0.70 | LOXL2 (0.53) | LOXL2LOXSMARCA2SMARCA4NOTUM | |
| SCHEMBL2327508 | 0.70 | NOS3 (0.59) | LOXL2LOXSMARCA2SMARCA4NOTUM | |
| SCHEMBL21223940 | 0.69 | TRPV4 (0.52) | MAP4K4HDAC4TRPV4 | |
| SCHEMBL20308676 | 0.69 | LOXL2 (0.48) | LOXL2LOXSMARCA2SMARCA4NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3746451-B1 | BENZYL-, (PYRIDIN-3-YL)METHYL- OR (PYRIDIN-4-YL)METHYL-SUBSTITUTED OXADIAZOLOPYRIDINE DERIVATIVES AS GHRELIN O-ACYL TRANSFERASE (GOAT) INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2023-07-12 | — | — | EP | disclosed |