Sugi Predict

Sugi Predict / Compounds / SCHEMBL2542628

SCHEMBL2542628

SCHEMBL2542628

Cc1cnc(N2CCN(C(=O)c3ccc(N4CC(C)(C)OC4=O)cc3N3CCCS3(=O)=O)CC2)c(C)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 7/20 0.37
▸ LMNA P02545 6/20 0.37
▸ MAPT P10636 3/20 0.37
▸ KIF18A Q8NI77 1/20 0.34
▸ KDM4E B2RXH2 2/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ CASP1 P29466 1/20 0.33
▸ CASP7 P55210 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.33
▸ PIK3C3 Q8NEB9 2/20 0.33
▸ THRB P10828 2/20 0.33
▸ HTT P42858 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ SLC6A9 P48067 1/20 0.32
▸ SLC6A5 Q9Y345 1/20 0.32
▸ OGA O60502 1/20 0.32
▸ GBA1 P04062 1/20 0.32
▸ GRM5 P41594 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2366871 0.91 TP53 (0.33) TP53LMNAMAPTKIF18AKDM4E
SCHEMBL2366088 0.90 SSTR5 (0.33) TP53LMNAMAPTKIF18AKDM4E
SCHEMBL2366138 0.87 TP53 (0.39) TP53LMNAMAPTKIF18AKDM4E
SCHEMBL14702945 0.86 TP53 (0.44) TP53LMNAMAPTKIF18AKDM4E
SCHEMBL2365880 0.85 LMNA (0.38) TP53LMNAMAPTKIF18AKDM4E
Hydrochloric Acid SCHEMBL14687113 0.85 TP53 (0.44) TP53LMNAMAPTKIF18AKDM4E
SCHEMBL14686504 0.85 MEN1 (0.46) TP53LMNAMAPTKIF18AKDM4E
SCHEMBL2366046 0.85 KIF18A (0.38) TP53LMNAMAPTKIF18AKDM4E
SCHEMBL2366036 0.85 KIF18A (0.38) TP53LMNAMAPTKIF18AKDM4E
SCHEMBL2366180 0.84 TP53 (0.40) TP53LMNAMAPTKIF18AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2364975-B1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORP (JP) 2013-06-12 — — EP disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 — — US disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 — — US disclosed
US-8354401-B2 Oxazolidinone amide aromatic compounds for supressing MMP-9 production MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-01-15 — — US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 — — US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 — — US disclosed
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110263571-A1 NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE MMP9, MMP10, MMP2 TP53 1433/4885LMNA 3668/4885MAPT 3728/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.