Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17260845 | 0.82 | ALDH1A1 (0.34) | HPGDHSD17B10ALDH1A1 | |
| SCHEMBL26814901 | 0.82 | KDM4E (0.33) | HPGDHSD17B10ALDH1A1 | |
| SCHEMBL27008050 | 0.81 | ALDH1A1 (0.31) | HPGDHSD17B10ALDH1A1 | |
| SCHEMBL27008083 | 0.78 | ALDH1A1 (0.31) | HPGDHSD17B10ALDH1A1 | |
| SCHEMBL25438598 | 0.78 | ALDH1A1 (0.31) | HPGDHSD17B10ALDH1A1 | |
| SCHEMBL27008199 | 0.77 | SMPD3 (0.32) | HPGDHSD17B10ALDH1A1 | |
| SCHEMBL27008088 | 0.77 | GRM4 (0.31) | — | |
| SCHEMBL27008131 | 0.76 | ALDH1A1 (0.30) | HPGDHSD17B10ALDH1A1 | |
| SCHEMBL25202785 | 0.75 | FFAR1 (0.34) | HPGDHSD17B10 | |
| SCHEMBL25432447 | 0.75 | HTT (0.38) | HPGDHSD17B10F2RL3ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4698541-A1 | THIENO[3,2-B]PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2026-02-25 | — | — | EP | disclosed |
| US-20250179092-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2025-06-05 | — | — | US | disclosed |
| EP-4308576-B1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2025-04-23 | — | — | EP | disclosed |
| EP-4490162-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-01-15 | — | — | EP | disclosed |
| WO-2024218207-A1 | THIENO[3,2-B]PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-10-24 | — | — | WO | disclosed |
| EP-4308576-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-01-24 | — | — | EP | disclosed |
| US-20240018163-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-18 | — | — | US | disclosed |
| US-20240018163-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-18 | — | — | US | disclosed |
| US-20240018163-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-18 | — | — | US | disclosed |
| WO-2023170115-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-09-14 | — | — | WO | disclosed |
| WO-2023170115-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-09-14 | — | — | WO | disclosed |
| WO-2022194801-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018163-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | NDUFS3, FOXM1, MT-ND1 | HPGD 2371/4885HSD17B10 933/4885F2RL3 1078/4885 |
| US-20250179092-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | ADORA1, P2RY1, CCNA1 | HPGD 706/4885HSD17B10 3473/4885F2RL3 604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.