Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31118776 | 0.78 | L3MBTL1 (0.40) | HTTALDH1A1 | |
| SCHEMBL477053 | 0.78 | ALDH1A1 (0.41) | HTTHPGDHSD17B10ALDH1A1NPC1 | |
| SCHEMBL1826272 | 0.78 | ALDH1A1 (0.41) | HTTHPGDHSD17B10ALDH1A1NPC1 | |
| SCHEMBL25433721 | 0.77 | HPGD (0.34) | HTTHPGDHSD17B10ALDH1A1SMN1; SMN2 | |
| Bromide SCHEMBL25241165 | 0.76 | ALDH1A1 (0.40) | HTTHPGDHSD17B10ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL21979887 | 0.76 | ALDH1A1 (0.40) | HTTHPGDHSD17B10ALDH1A1NPC1 | |
| SCHEMBL26978235 | 0.76 | ASPH (0.41) | HSD17B10ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23813584 | 0.75 | ALDH1A1 (0.37) | HPGDHSD17B10ALDH1A1KMT2AMEN1 | |
| SCHEMBL25435839 | 0.75 | HPGD (0.31) | HTTHPGDHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL1826708 | 0.75 | ALDH1A1 (0.39) | HTTHPGDHSD17B10ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4698541-A1 | THIENO[3,2-B]PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2026-02-25 | — | — | EP | disclosed |
| US-20250179092-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2025-06-05 | — | — | US | disclosed |
| EP-4308572-B1 | NEW THIENOPYRIMIDINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2025-04-23 | — | — | EP | disclosed |
| EP-4308576-B1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2025-04-23 | — | — | EP | disclosed |
| EP-4490162-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-01-15 | — | — | EP | disclosed |
| EP-4308577-B1 | NEW THIADIAZOLOPYRIMIDONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2024-12-25 | — | — | EP | disclosed |
| CN-118843634-A | Pyrido [1,2-a ] pyrimidin-4-one derivatives | 豪夫迈·罗氏有限公司 | 2024-10-25 | — | — | CN | disclosed |
| WO-2024218207-A1 | THIENO[3,2-B]PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-10-24 | — | — | WO | disclosed |
| EP-4308576-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-01-24 | — | — | EP | disclosed |
| EP-4308572-A1 | NEW THIENOPYRIMIDINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-01-24 | — | — | EP | disclosed |
| EP-4308577-A1 | NEW THIADIAZOLOPYRIMIDONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-01-24 | — | — | EP | disclosed |
| US-20240018163-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-18 | — | — | US | disclosed |
| US-20240010659-A1 | NEW THIADIAZOLOPYRIMIDONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-11 | — | — | US | disclosed |
| US-20240002407-A1 | THIENOPYRIMIDINONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-01-04 | — | — | US | disclosed |
| CN-116997555-A | Novel thienopyrimidinone derivatives | 豪夫迈·罗氏有限公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-116981674-A | Novel thiazolopyrimidinone derivatives | 豪夫迈·罗氏有限公司 | 2023-10-31 | — | — | CN | disclosed |
| WO-2023170115-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-09-14 | — | — | WO | disclosed |
| WO-2022194801-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-09-22 | — | — | WO | disclosed |
| WO-2022194800-A1 | NEW THIENOPYRIMIDINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-09-22 | — | — | WO | disclosed |
| WO-2022194802-A1 | NEW THIADIAZOLOPYRIMIDONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2022-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018163-A1 | NEW THIAZOLOPYRIMIDINONE DERIVATIVES | NDUFS3, FOXM1, MT-ND1 | HTT 1954/4885HPGD 2371/4885HSD17B10 933/4885 |
| US-20240010659-A1 | NEW THIADIAZOLOPYRIMIDONE DERIVATIVES | TBXA2R, ADRA1D, TBXAS1 | HTT 3183/4885HPGD 1013/4885HSD17B10 1734/4885 |
| US-20240002407-A1 | THIENOPYRIMIDINONE DERIVATIVES | XDH, P2RX4, TBXA2R | HTT 2120/4885HPGD 865/4885HSD17B10 2601/4885 |
| US-20250179092-A1 | PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES | ADORA1, P2RY1, CCNA1 | HTT 2577/4885HPGD 706/4885HSD17B10 3473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.