Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25094185 | 0.84 | NOTUM (0.42) | GRM2ALDH1A1NOTUMHTR3EHTR3B | |
| SCHEMBL12452783 | 0.83 | ALDH1A1 (0.46) | ALDH1A1NOTUMHTR3EHTR3BHTR1D | |
| SCHEMBL24243092 | 0.81 | ALDH1A1 (0.41) | GRM2ALDH1A1NOTUMHTR3EHTR3B | |
| SCHEMBL24243037 | 0.81 | CHRNB4 (0.42) | GRM2ALDH1A1HTR3EHTR3BHTR1D | |
| SCHEMBL12017183 | 0.78 | ALDH1A1 (0.49) | ALDH1A1NOTUMHTR3EHTR3BHTR1D | |
| SCHEMBL24243040 | 0.78 | ESR1 (0.42) | GRM2ALDH1A1NOTUMHTR3EHTR3B | |
| SCHEMBL26796037 | 0.77 | HSD11B1 (0.41) | ALDH1A1SIGMAR1MAPTTSHRACACB | |
| SCHEMBL18210659 | 0.76 | PRMT6 (0.50) | ALDH1A1NOTUMHTR3EHTR3BHTR1D | |
| SCHEMBL271333 | 0.76 | PRMT6 (0.50) | ALDH1A1NOTUMHTR3EHTR3BHTR1D | |
| SCHEMBL23510813 | 0.76 | KHK (0.47) | ALDH1A1NOTUMHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648254-B2 | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling | KUMQUAT BIOSCIENCES INC. (US) | 2023-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11648254-B2 | Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling | KRAS, NRAS, BRAF | GRM2 3078/4885ALDH1A1 1973/4885NOTUM 4831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.