SCHEMBL25458022

SCHEMBL25458022

CC(C)C(=O)c1conc1-c1ccc(Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GABRA5 P31644 12/20 0.46
GPBAR1 Q8TDU6 3/20 0.45
FFAR4 Q5NUL3 1/20 0.41
PTPN1 P18031 1/20 0.41
LMNA P02545 1/20 0.39
CNR1 P21554 2/20 0.37
CNR2 P34972 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6004036 0.83 GPBAR1 (0.45) GABRA5GPBAR1FFAR4PTPN1
SCHEMBL2929499 0.81 CDH1 (0.46) GPBAR1FFAR4PTPN1LMNA
SCHEMBL25562790 0.79 GPBAR1 (0.42) GABRA5GPBAR1FFAR4PTPN1CNR1
SCHEMBL27946184 0.79 SLC6A3 (0.51) GABRA5GPBAR1PTPN1LMNA
SCHEMBL4762391 0.77 GABRA5 (0.42) GABRA5GPBAR1FFAR4PTPN1
SCHEMBL2929533 0.75 SMN1; SMN2 (0.52) FFAR4LMNA
SCHEMBL22143653 0.70 CYP19A1 (0.54) GABRA5GPBAR1FFAR4PTPN1LMNA
SCHEMBL10044967 0.70 CHRNA4 (0.43)
SCHEMBL2928527 0.69 NOTUM (0.51) GABRA5FFAR4
SCHEMBL5772712 0.69 FFAR4 (0.66) GABRA5FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230227437-A1 IMMUNOMODULATOR HITGEN INC (CN) 2023-07-20 US disclosed
US-20230159465-A1 IMMUNOMODULATOR HITGEN INC. (CN) 2023-05-25 US disclosed
EP-4177249-A1 IMMUNOMODULATOR Hitgen Inc. (CN) 2023-05-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230159465-A1 IMMUNOMODULATOR IL2, IL17A, IL2RA GABRA5 657/4885GPBAR1 156/4885FFAR4 1984/4885
US-20230227437-A1 IMMUNOMODULATOR IL17A, IL2, IL2RA GABRA5 521/4885GPBAR1 210/4885FFAR4 2419/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.