Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CDH1 | P12830 | 1/20 | 0.39 |
| ▸ | APC | P25054 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929499 | 0.85 | CDH1 (0.46) | GPBAR1PTPN1FFAR4ALDH1A1SMN1; SMN2 | |
| SCHEMBL4762391 | 0.83 | GABRA5 (0.42) | GPBAR1PTPN1FFAR4GABRA5POLB | |
| SCHEMBL2468990 | 0.83 | PTGS2 (0.45) | GPBAR1GABRA5ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL25458022 | 0.83 | GABRA5 (0.46) | GPBAR1PTPN1FFAR4GABRA5 | |
| SCHEMBL25562790 | 0.83 | GPBAR1 (0.42) | GPBAR1PTPN1FFAR4GABRA5CDH1 | |
| SCHEMBL27946184 | 0.83 | SLC6A3 (0.51) | GPBAR1PTPN1GABRA5ALDH1A1SMN1; SMN2 | |
| SCHEMBL2929533 | 0.79 | SMN1; SMN2 (0.52) | FFAR4ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL22143653 | 0.73 | CYP19A1 (0.54) | GPBAR1PTPN1FFAR4GABRA5SMN1; SMN2 | |
| SCHEMBL10519102 | 0.72 | SMN1; SMN2 (0.43) | ALDH1A1SMN1; SMN2KDM4ERAB9AMAPT | |
| SCHEMBL402939 | 0.71 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KDM4EHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | KALYPSYS, INC. | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | MAPK1, MAP3K1, MAPK4 | GPBAR1 2708/4885PTPN1 255/4885FFAR4 3706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.