Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDH1 | P12830 | 2/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.46 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.46 |
| ▸ | APC | P25054 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 5/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004036 | 0.85 | GPBAR1 (0.45) | CDH1CTNNB1TCF7L2APCNPC1 | |
| SCHEMBL4024790 | 0.84 | ALDH1A1 (0.45) | MEN1KMT2AL3MBTL1DHODHTSHR | |
| SCHEMBL1225673 | 0.84 | PTGS2 (0.44) | NPC1RAB9APTPN1MEN1KMT2A | |
| SCHEMBL402939 | 0.83 | ALDH1A1 (0.46) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL1776666 | 0.83 | MAPK13 (0.49) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL4022249 | 0.83 | TPMT (0.39) | CTNNB1PTPN1KMT2AKDM4EMAPK14 | |
| SCHEMBL27934992 | 0.82 | PTGS2 (0.43) | NPC1RAB9APTPN1MEN1KMT2A | |
| SCHEMBL4025736 | 0.82 | PTPN1 (0.37) | RAB9AFFAR4PTPN1SMN1; SMN2 | |
| SCHEMBL25458022 | 0.81 | GABRA5 (0.46) | GPBAR1FFAR4PTPN1LMNA | |
| SCHEMBL27946184 | 0.81 | SLC6A3 (0.51) | NPC1RAB9AGPBAR1PTPN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229383-B1 | ISOXAZOLO-PYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-01-18 | — | — | EP | disclosed |
| EP-2768827-B1 | PROCESS FOR THE PREPARATION OF ISOXAZOLYL-METHOXY-NICOTINIC ACIDS | HOFFMANN LA ROCHE (CH) | 2016-11-23 | — | — | EP | disclosed |
| EP-2767536-B1 | Isoxazolo-pyridine derivatives | HOFFMANN LA ROCHE (CH) | 2015-09-02 | — | — | EP | disclosed |
| US-9073908-B2 | Isoxazolo-pyridine derivatives | ROCHE PALO ALTO LLC (US) | 2015-07-07 | — | — | US | disclosed |
| EP-2227467-B1 | ISOXAZOLO-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-12-31 | — | — | EP | disclosed |
| US-8877782-B2 | Isoxazolo-pyridine derivatives | ROCHE PALO ALTO LLC (US) | 2014-11-04 | — | — | US | disclosed |
| US-8877783-B2 | Isoxazolo-pyridine derivatives | ROCHE PALO ALTO LLC (US) | 2014-11-04 | — | — | US | disclosed |
| US-8846719-B2 | Isoxazolo-pyridine derivatives | ROCHE PALO ALTO LLC (US) | 2014-09-30 | — | — | US | disclosed |
| EP-2768827-A1 | PROCESS FOR THE PREPARATION OF ISOXAZOLYL-METHOXY-NICOTINIC ACIDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-27 | — | — | EP | disclosed |
| EP-2767536-A1 | ISOXAZOLO-PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2014-08-20 | — | — | EP | disclosed |
| US-20120184538-A1 | ISOXAZOLO-PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2012-07-19 | — | — | US | disclosed |
| US-7902201-B2 | Isoxazolo-pyrazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-03-08 | — | — | US | disclosed |
| CN-101889010-A | Isoxazolo-pyridine derivatives | HOFFMANN LA ROCHE | 2010-11-17 | — | — | CN | disclosed |
| CN-101883769-A | Isoxazole-pyrazine derivatives | HOFFMANN LA ROCHE | 2010-11-10 | — | — | CN | disclosed |
| US-20100256154-A1 | ISOXAZOLO-PYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2010-10-07 | — | — | US | disclosed |
| EP-2229383-A1 | ISOXAZOLO-PYRAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| EP-2227467-A1 | ISOXAZOLO-PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009071476-A1 | ISOXAZOLO-PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009071464-A1 | ISOXAZOLO-PYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-11 | — | — | WO | disclosed |
| US-20090143371-A1 | ISOXAZOLE-PYRIDINE DERIVATIVES | ROCHE PALO ALTO LLC | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143371-A1 | ISOXAZOLE-PYRIDINE DERIVATIVES | GABRA5, GABRA1, CHRNA5 | CDH1 4439/4885CTNNB1 2811/4885TCF7L2 1306/4885 |
| US-20100256154-A1 | ISOXAZOLO-PYRAZINE DERIVATIVES | GABRA5, GRIK5, GABRA4 | CDH1 4578/4885CTNNB1 2777/4885TCF7L2 813/4885 |
| US-20120184538-A1 | ISOXAZOLO-PYRIDINE DERIVATIVES | GABRA5, GABRA1, GABRA4 | CDH1 4402/4885CTNNB1 2587/4885TCF7L2 1029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.