SCHEMBL2546320

SCHEMBL2546320

Cc1ccccc1-n1ncc2ccccc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.46
ALDH1A1 P00352 3/20 0.46
LMNA P02545 2/20 0.46
HIF1A Q16665 2/20 0.46
KDM4E B2RXH2 2/20 0.46
MITF O75030 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
HTT P42858 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
TP53 P04637 1/20 0.46
SMO Q99835 1/20 0.45
CYP11B1 P15538 2/20 0.43
CYP11B2 P19099 2/20 0.43
MAPK14 Q16539 1/20 0.43
GSK3B P49841 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15839178 0.83 CYP17A1 (0.45) CYP1A2CYP11B1CYP11B2GSK3BFLT3
SCHEMBL11888511 0.81 CYP11B1 (0.43) ALDH1A1LMNAMITFCYP1A2CYP3A4
SCHEMBL16574155 0.80 TP53 (0.43) ALDH1A1LMNATP53CYP11B1CYP11B2
SCHEMBL23840290 0.78 PDE10A (0.45) ALDH1A1LMNAKDM4EMITFCYP1A2
SCHEMBL14688369 0.78 CYP11B1 (0.40) KDM4ECYP1A2CYP11B1CYP11B2PDE10A
SCHEMBL14688616 0.78 PDE10A (0.43) KDM4ECYP1A2HTTTP53CYP11B1
SCHEMBL1135647 0.78 SCN9A (0.49) SMOCYP11B1CYP11B2MAPK14
SCHEMBL29573544 0.78 SCN9A (0.49) SMOCYP11B1CYP11B2MAPK14
SCHEMBL2188830 0.78 CYP11B1 (0.48) TSHRALDH1A1LMNAKDM4ECYP1A2
SCHEMBL3020579 0.78 PDE10A (0.43) LMNACYP1A2CYP11B1CYP11B2PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11818946-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-11-14 US disclosed
US-11765966-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-09-19 US disclosed
US-20230276696-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORP (US) 2023-08-31 US disclosed
US-20230270003-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-08-24 US disclosed
US-11685756-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-06-27 US disclosed
US-20230200211-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2023-06-22 US disclosed
US-11683981-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-06-20 US disclosed
US-11672165-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2023-06-06 US disclosed
US-10680187-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2020-06-09 US disclosed
US-20190189935-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION 2019-06-20 US disclosed
US-20180130962-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2018-05-10 US disclosed
US-20180130962-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2018-05-10 US disclosed
US-9771375-B2 Indazole compounds useful as ketohexokinase inhibitors JANSSEN PHARMACEUTICA NV (BE) 2017-09-26 US disclosed
CN-102939283-B Indazole compounds useful as ketohexokinase inhibitors JANSSEN PHARMACEUTICA NV 2015-06-03 CN disclosed
US-20140336170-A1 INDAZOLE COMPOUNDS USEFUL AS KETOHEXOKINASE INHIBITORS JANSSEN PHARMACEUTICA NV (US) 2014-11-13 US disclosed
US-8822447-B2 Indazole compounds useful as ketohexokinase inhibitors JANSSEN PHARMACEUTICA NV (BE) 2014-09-02 US disclosed
CN-102939283-A Indazole compounds useful as ketohexokinase inhibitors JANSSEN PHARMACEUTICA NV 2013-02-20 CN disclosed
US-20110263559-A1 INDAZOLE COMPOUNDS USEFUL AS KETOHEXOKINASE INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2011-10-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11685756-B2 Organic electroluminescent materials and devices OCIAD1, OCIAD2, OPRD1 TSHR 3424/4885ALDH1A1 2254/4885LMNA 3673/4885
US-20140336170-A1 INDAZOLE COMPOUNDS USEFUL AS KETOHEXOKINASE INHIBITORS KHK, GCK, GCKR TSHR 3688/4885ALDH1A1 1451/4885LMNA 4091/4885
US-20190189935-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OR10J3, OXER1, CHRM4 TSHR 196/4885ALDH1A1 1404/4885LMNA 2695/4885
US-20180130962-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES TYR, ORC3, LEF1 TSHR 2533/4885ALDH1A1 303/4885LMNA 1521/4885
US-11818946-B2 Organic electroluminescent materials and devices OCIAD1, OCIAD2, AOC3 TSHR 3108/4885ALDH1A1 705/4885LMNA 572/4885
US-20230270003-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OXER1, CHRM1, OSBPL8 TSHR 1499/4885ALDH1A1 424/4885LMNA 648/4885
US-20230200211-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OPRM1, OCIAD1 TSHR 1460/4885ALDH1A1 412/4885LMNA 701/4885
US-10680187-B2 Organic electroluminescent materials and devices TYR, ORC3, LEF1 TSHR 2533/4885ALDH1A1 303/4885LMNA 1521/4885
US-20230276696-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD2, OCIAD1, PORCN TSHR 4754/4885ALDH1A1 3156/4885LMNA 2148/4885
US-11683981-B2 Organic electroluminescent materials and devices OXER1, CHRM1, OSBPL8 TSHR 1499/4885ALDH1A1 424/4885LMNA 648/4885
US-11765966-B2 Organic electroluminescent materials and devices L1CAM, EPCAM, EPM2A TSHR 4074/4885ALDH1A1 1028/4885LMNA 572/4885
US-20110263559-A1 INDAZOLE COMPOUNDS USEFUL AS KETOHEXOKINASE INHIBITORS KHK, GCK, GCKR TSHR 3688/4885ALDH1A1 1451/4885LMNA 4091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.