SCHEMBL25464969

SCHEMBL25464969

Cc1c(P)cccc1-c1ccc(Oc2[nH]nnc2C(=O)O)cc1

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ HAO1 Q9UJM8 8/20 0.34
▸ PRKAB2 O43741 2/20 0.33
▸ PRKAG1 P54619 2/20 0.33
▸ PRKAA2 P54646 2/20 0.33
▸ PRKAA1 Q13131 2/20 0.33
▸ PRKAG3 Q9UGI9 2/20 0.33
▸ PRKAG2 Q9UGJ0 2/20 0.33
▸ PRKAB1 Q9Y478 2/20 0.33
▸ MGLL Q99685 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21312600 0.83 PPARG (0.43) HAO1PRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL25464506 0.82 PRKAG1 (0.38) HAO1PRKAG1PRKAA1PRKAB1
SCHEMBL25463985 0.81 MKNK1 (0.46) HAO1
SCHEMBL25464287 0.81 HAO1 (0.38) HAO1PRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL25463615 0.81 HAO1 (0.38) HAO1PRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL23319997 0.80 DHODH (0.40) HAO1PRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL23320028 0.79 PPARG (0.48) —
SCHEMBL29968357 0.79 PPARG (0.48) —
SCHEMBL21296970 0.79 ALPL (0.42) HAO1PRKAG1PRKAA1PRKAB1MGLL
SCHEMBL21296854 0.79 HAO1 (0.44) HAO1PRKAG1PRKAA1PRKAB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-05-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS XDH, DUOX1, PNPO HAO1 6/4885PRKAB2 3843/4885PRKAG1 2945/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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