SCHEMBL25464506

SCHEMBL25464506

Cc1c(P)cc(-c2ccc(Oc3[nH]nnc3C(=O)O)cc2)cc1P

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ PRKAG1 P54619 1/20 0.38
▸ PRKAA1 Q13131 1/20 0.38
▸ PRKAB1 Q9Y478 1/20 0.38
▸ HAO1 Q9UJM8 11/20 0.35
▸ ALPL P05186 2/20 0.35
▸ CA9 Q16790 1/20 0.35
▸ MCL1 Q07820 2/20 0.34
▸ DHODH Q02127 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25465250 0.88 PRKAG1 (0.39) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL21296970 0.84 ALPL (0.42) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL21296952 0.82 RXRA (0.51) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL25464969 0.82 HAO1 (0.34) PRKAG1PRKAA1PRKAB1HAO1
SCHEMBL21296847 0.82 PRKAG1 (0.51) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL21296854 0.82 HAO1 (0.44) PRKAG1PRKAA1PRKAB1HAO1MCL1
SCHEMBL21296913 0.81 RXRA (0.45) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL21312672 0.81 HAO1 (0.41) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL21312442 0.80 GAA (0.45) HAO1ALPL
SCHEMBL23319961 0.80 HAO1 (0.39) PRKAG1PRKAA1PRKAB1HAO1ALPL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-05-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS XDH, DUOX1, PNPO PRKAG1 2945/4885PRKAA1 2067/4885PRKAB1 3254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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