SCHEMBL254686

SCHEMBL254686

Nc1ccccc1-c1ccc(C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)NO)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 1/20 0.39
MMP9 P14780 1/20 0.39
ADAM17 P78536 1/20 0.39
CTSK P43235 3/20 0.39
HPGDS O60760 1/20 0.38
CTSS P25774 3/20 0.37
CTSB P07858 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
HDAC8 Q9BY41 2/20 0.36
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36
F10 P00742 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL254727 0.84 CTSS (0.41) CTSKHPGDSCTSSCTSBL3MBTL1
SCHEMBL19262836 0.83 CTSK (0.35) CTSK
SCHEMBL15235744 0.81
SCHEMBL201669 0.81 L3MBTL1 (0.43) CTSKCTSSCTSBL3MBTL1HDAC8
SCHEMBL1912268 0.79 MMP2 (0.44) MMP2MMP9ADAM17HPGDSCTSB
SCHEMBL19262696 0.77 FFAR1 (0.38)
SCHEMBL15235745 0.76
SCHEMBL201033 0.76 HDAC3 (0.39) L3MBTL1HDAC8HDAC3HDAC4HDAC1
SCHEMBL201034 0.76 HDAC3 (0.39) L3MBTL1HDAC8HDAC3HDAC4HDAC1
SCHEMBL5717643 0.75 HPGDS (0.46) HPGDS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012031298-A2 ETHYNYLBENZENE DERIVATIVES DUKE UNIVERSITY (US) 2012-03-08 WO disclosed