SCHEMBL254747

SCHEMBL254747

COc1ccc(CCc2cnc3c(N)nc4cc(C(=O)C(F)(F)P(=O)(O)O)ccc4c3c2)c(C)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30575419 1.00 TLR7 (1.00) TLR7
SCHEMBL1527534 0.91 TLR7 (0.83) TLR7
SCHEMBL18598574 0.90 TLR7 (0.82) TLR7
SCHEMBL12841274 0.89 TLR7 (0.80) TLR7
SCHEMBL15355075 0.88 TLR7 (0.79) TLR7
SCHEMBL1527529 0.88 TLR7 (1.00) TLR7
SCHEMBL30575439 0.88 TLR7 (1.00) TLR7
SCHEMBL12723160 0.86 TLR7 (0.81) TLR7
SCHEMBL255046 0.86 TLR7 (0.78) TLR7
SCHEMBL1534100 0.84 TLR7 (0.85) TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240009215-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING SOLID TUMORS BY INTRATUMORAL ADMINISTRATION NOVARTIS AG (CH) 2024-01-11 US claimed
US-11752162-B2 Compounds and compositions for treating solid tumors by intratumoral administration NOVARTIS AG (CH) 2023-09-12 US claimed
US-20210154214-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING SOLID TUMORS BY INTRATUMORAL ADMINISTRATION NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. DBA THE GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION 2021-05-27 US claimed
EP-3624806-A1 COMPOSITIONS COMPRISING NAPHTHYRIDINE DERIVATIVES AND ALUMINIUM ADJUVANT FOR USE IN TREATING SOLID TUMORS Novartis AG (CH) 2020-03-25 EP claimed
CN-110636848-A Composition comprising a naphthyridine derivative and an aluminium adjuvant for the treatment of solid tumours 诺华股份有限公司 2019-12-31 CN claimed
WO-2018211453-A1 COMPOSITIONS COMPRISING NAPHTHYRIDINE DERIVATIVES AND ALUMINIUM ADJUVANT FOR USE IN TREATING SOLID TUMORS NOVARTIS AG (CH) 2018-11-22 WO claimed
US-9950062-B2 Compounds and compositions as TLR activity modulators GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2018-04-24 US claimed
EP-2440245-B1 BENZONAPHTHYRIDINE-CONTAINING VACCINES GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2017-12-06 EP claimed
EP-2473508-B1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2017-03-08 EP claimed
US-9517263-B2 Benzonaphthyridine-containing vaccines GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2016-12-13 US claimed
US-20150225432-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2015-08-13 US claimed
EP-2459216-B1 IMMUNOGENIC COMPOSITIONS INCLUDING TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2013-10-30 EP claimed
US-20120263753-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES NOVARTIS AG (CH) 2012-10-18 US claimed
US-20120237546-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2012-09-20 US claimed
EP-2459216-A2 IMMUNOGENIC COMPOSITIONS INCLUDING TLR ACTIVITY MODULATORS Novartis AG (CH) 2012-06-06 EP claimed
EP-2440245-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES Novartis AG (CH) 2012-04-18 EP claimed
WO-2011027222-A2 IMMUNOGENIC COMPOSITIONS INCLUDING TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2011-03-10 WO claimed
US-20110053893-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2011-03-03 US claimed
WO-2010144734-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES NOVARTIS AG (CH) 2010-12-16 WO claimed
US-20240009215-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING SOLID TUMORS BY INTRATUMORAL ADMINISTRATION NOVARTIS AG (CH) 2024-01-11 US disclosed
US-11752162-B2 Compounds and compositions for treating solid tumors by intratumoral administration NOVARTIS AG (CH) 2023-09-12 US disclosed
US-11752162-B2 Compounds and compositions for treating solid tumors by intratumoral administration NOVARTIS AG (CH) 2023-09-12 US disclosed
US-11752162-B2 Compounds and compositions for treating solid tumors by intratumoral administration NOVARTIS AG (CH) 2023-09-12 US disclosed
CN-116473981-A Composition comprising naphthyridine derivatives and aluminium adjuvants for the treatment of solid tumors 诺华股份有限公司 2023-07-25 CN disclosed
US-20210154214-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING SOLID TUMORS BY INTRATUMORAL ADMINISTRATION NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. DBA THE GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION 2021-05-27 US disclosed
US-20210154214-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING SOLID TUMORS BY INTRATUMORAL ADMINISTRATION NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC. DBA THE GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION 2021-05-27 US disclosed
EP-3624806-A1 COMPOSITIONS COMPRISING NAPHTHYRIDINE DERIVATIVES AND ALUMINIUM ADJUVANT FOR USE IN TREATING SOLID TUMORS Novartis AG (CH) 2020-03-25 EP disclosed
CN-110636848-A Composition comprising a naphthyridine derivative and an aluminium adjuvant for the treatment of solid tumours 诺华股份有限公司 2019-12-31 CN disclosed
WO-2018211453-A1 COMPOSITIONS COMPRISING NAPHTHYRIDINE DERIVATIVES AND ALUMINIUM ADJUVANT FOR USE IN TREATING SOLID TUMORS NOVARTIS AG (CH) 2018-11-22 WO disclosed
US-20180169204-A1 COMBINATION VACCINES WITH LOWER DOSES OF ANTIGEN AND/OR ADJUVANT GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2018-06-21 US disclosed
US-20180169204-A1 COMBINATION VACCINES WITH LOWER DOSES OF ANTIGEN AND/OR ADJUVANT GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2018-06-21 US disclosed
US-9950062-B2 Compounds and compositions as TLR activity modulators GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2018-04-24 US disclosed
US-9950062-B2 Compounds and compositions as TLR activity modulators GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2018-04-24 US disclosed
US-9950062-B2 Compounds and compositions as TLR activity modulators GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2018-04-24 US disclosed
EP-2440245-B1 BENZONAPHTHYRIDINE-CONTAINING VACCINES GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2017-12-06 EP disclosed
US-9597326-B2 Benzonapthyridine compositions and uses thereof GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2017-03-21 US disclosed
US-9597326-B2 Benzonapthyridine compositions and uses thereof GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2017-03-21 US disclosed
EP-2473508-B1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2017-03-08 EP disclosed
EP-2473508-B1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2017-03-08 EP disclosed
US-9517263-B2 Benzonaphthyridine-containing vaccines GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2016-12-13 US disclosed
US-9517263-B2 Benzonaphthyridine-containing vaccines GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2016-12-13 US disclosed
US-9517263-B2 Benzonaphthyridine-containing vaccines GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2016-12-13 US disclosed
US-20160213776-A1 ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2016-07-28 US disclosed
US-20160213776-A1 ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2016-07-28 US disclosed
US-9375471-B2 Adjuvanted formulations of booster vaccines GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2016-06-28 US disclosed
US-9375471-B2 Adjuvanted formulations of booster vaccines GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2016-06-28 US disclosed
US-9315530-B2 Adsorption of immunopotentiators to insoluble metal salts NOVARTIS AG (CH) 2016-04-19 US disclosed
US-9315530-B2 Adsorption of immunopotentiators to insoluble metal salts NOVARTIS AG (CH) 2016-04-19 US disclosed
US-20150225432-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2015-08-13 US disclosed
US-20150225432-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2015-08-13 US disclosed
US-20150225432-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2015-08-13 US disclosed
US-9045470-B2 Compounds and compositions as TLR activity modulators IRM LLC (BM) 2015-06-02 US disclosed
US-9045470-B2 Compounds and compositions as TLR activity modulators IRM LLC (BM) 2015-06-02 US disclosed
US-9045470-B2 Compounds and compositions as TLR activity modulators IRM LLC (BM) 2015-06-02 US disclosed
US-20140112950-A1 COMBINATION VACCINES WITH LOWER DOSES OF ANTIGEN AND/OR ADJUVANT GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2014-04-24 US disclosed
US-20140112950-A1 COMBINATION VACCINES WITH LOWER DOSES OF ANTIGEN AND/OR ADJUVANT GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2014-04-24 US disclosed
EP-2719395-A1 Adsorption of immunopotentiators to insoluble metal salts Novartis AG (CH) 2014-04-16 EP disclosed
EP-2480253-B1 ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS NOVARTIS AG (CH) 2014-01-22 EP disclosed
EP-2459216-B1 IMMUNOGENIC COMPOSITIONS INCLUDING TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2013-10-30 EP disclosed
US-20130274465-A1 ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS IRM LLC (BM) 2013-10-17 US disclosed
US-20130274465-A1 ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS IRM LLC (BM) 2013-10-17 US disclosed
US-20130122042-A1 BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF NOVARTIS AG (CH) 2013-05-16 US disclosed
US-20130122042-A1 BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF NOVARTIS AG (CH) 2013-05-16 US disclosed
US-20120263753-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES NOVARTIS AG (CH) 2012-10-18 US disclosed
US-20120263753-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES NOVARTIS AG (CH) 2012-10-18 US disclosed
US-20120263753-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES NOVARTIS AG (CH) 2012-10-18 US disclosed
US-20120237546-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2012-09-20 US disclosed
US-20120237546-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2012-09-20 US disclosed
US-20120237546-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2012-09-20 US disclosed
US-20120177681-A1 Formulation of immunopotentiators GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2012-07-12 US disclosed
US-20120177681-A1 Formulation of immunopotentiators GLAXOSMITHKLINE BIOLOGICALS SA (BE) 2012-07-12 US disclosed
EP-2473508-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2012-07-11 EP disclosed
EP-2459216-A2 IMMUNOGENIC COMPOSITIONS INCLUDING TLR ACTIVITY MODULATORS Novartis AG (CH) 2012-06-06 EP disclosed
WO-2012031140-A1 ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS NOVARTIS AG (CH) 2012-03-08 WO disclosed
WO-2011049677-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2011-04-28 WO disclosed
WO-2011049677-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2011-04-28 WO disclosed
WO-2011027222-A2 IMMUNOGENIC COMPOSITIONS INCLUDING TLR ACTIVITY MODULATORS NOVARTIS AG (CH) 2011-03-10 WO disclosed
US-20110053893-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2011-03-03 US disclosed
US-20110053893-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2011-03-03 US disclosed
US-20110053893-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2011-03-03 US disclosed
US-20110053893-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2011-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180169204-A1 COMBINATION VACCINES WITH LOWER DOSES OF ANTIGEN AND/OR ADJUVANT LY96, MYD88, CD69 TLR7 33/4885
US-20150225432-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS TLR1, TLR6, TLR7 TLR7 3/4885
US-20210154214-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING SOLID TUMORS BY INTRATUMORAL ADMINISTRATION TLR7, TLR9, TLR3 TLR7 1/4885
US-20140112950-A1 COMBINATION VACCINES WITH LOWER DOSES OF ANTIGEN AND/OR ADJUVANT LY96, MYD88, CD69 TLR7 33/4885
US-20120263753-A1 BENZONAPHTHYRIDINE-CONTAINING VACCINES LY96, TLR3, GABRA4 TLR7 7/4885
US-11752162-B2 Compounds and compositions for treating solid tumors by intratumoral administration TLR7, TLR9, TLR3 TLR7 1/4885
US-20120237546-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS TLR1, TLR6, TLR7 TLR7 3/4885
US-20110053893-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS TLR1, TLR6, TLR7 TLR7 3/4885
US-20130274465-A1 ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS CD69, CD209, CD4 TLR7 776/4885
US-20240009215-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING SOLID TUMORS BY INTRATUMORAL ADMINISTRATION TLR7, TLR9, TLR3 TLR7 1/4885
US-20130122042-A1 BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF HAMP, MAVS, MYD88 TLR7 59/4885
US-20120177681-A1 Formulation of immunopotentiators CD69, CD4, ICOS TLR7 324/4885
US-20160213776-A1 ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS CD69, CD209, CD4 TLR7 776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.