Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 8/20 | 0.41 |
| ▸ | BACE1 | P56817 | 8/20 | 0.41 |
| ▸ | BCHE | P06276 | 6/20 | 0.41 |
| ▸ | FABP6 | P51161 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2551564 | 0.83 | HRH3 (0.45) | HRH3POLBACHEBACE1BCHE | |
| SCHEMBL2554540 | 0.83 | KDM4E (0.47) | HRH3POLBACHEBACE1BCHE | |
| SCHEMBL2555072 | 0.70 | KCNH2 (0.49) | HRH3POLBFABP6MEN1KMT2A | |
| SCHEMBL2555109 | 0.70 | KDM4E (0.48) | HRH3POLBACHEBACE1BCHE | |
| SCHEMBL2547933 | 0.70 | KDM4E (0.48) | HRH3POLBACHEBACE1BCHE | |
| SCHEMBL7716908 | 0.70 | KDM4E (0.48) | HRH3POLBACHEBACE1BCHE | |
| SCHEMBL4940261 | 0.69 | HRH3 (0.58) | HRH3POLBHDAC1 | |
| SCHEMBL7716923 | 0.69 | SMN1; SMN2 (0.54) | HRH3POLBFABP6MEN1KMT2A | |
| SCHEMBL7356760 | 0.69 | DRD2 (0.56) | — | |
| SCHEMBL20492777 | 0.69 | ACHE (0.68) | ACHEBACE1BCHEFABP6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121309-A1 | PHENYL SULFONYL DERIVATIVES AND THEIR USE AS HISTAMINE H3 ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-10-06 | — | — | WO | disclosed |
| WO-2011121309-A1 | PHENYL SULFONYL DERIVATIVES AND THEIR USE AS HISTAMINE H3 ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-10-06 | — | — | WO | disclosed |