Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | STING1 | Q86WV6 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25485987 | 0.88 | MEN1 (0.46) | KDRF10PIK3C3BRAFMAPT | |
| SCHEMBL23840461 | 0.86 | PIK3C3 (0.39) | F10PIK3C3BRAFMAPTKMT2A | |
| SCHEMBL23840408 | 0.86 | AURKA (0.52) | PIK3C3MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL23840439 | 0.84 | ROCK2 (0.40) | PIK3C3BRAFMAPTKMT2AMEN1 | |
| SCHEMBL23840635 | 0.83 | POLB (0.42) | PIK3C3BRAFMAPTKMT2AMEN1 | |
| SCHEMBL25485956 | 0.83 | NAMPT (0.52) | PIK3C3MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL25486202 | 0.82 | SMN1; SMN2 (0.53) | PIK3C3MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL23840436 | 0.82 | MEN1 (0.45) | PIK3C3BRAFMAPTKMT2AMEN1 | |
| SCHEMBL23840446 | 0.82 | POLB (0.48) | PIK3C3BRAFMAPTKMT2AMEN1 | |
| SCHEMBL23840544 | 0.81 | ALDH1A1 (0.47) | PIK3C3MAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159509-A1 | PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159509-A1 | PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | TRAP1, PINK1, PPM1D | KDR 2694/4885FGFR1 1296/4885F10 4629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.