Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23840352 | 0.91 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1LMNAMAPK1RAB9A | |
| SCHEMBL23840380 | 0.88 | MEN1 (0.54) | SMN1; SMN2ALDH1A1LMNAMAPK1RAB9A | |
| SCHEMBL23840408 | 0.86 | AURKA (0.52) | SMN1; SMN2ALDH1A1LMNAMAPK1MEN1 | |
| SCHEMBL25485963 | 0.86 | MEN1 (0.40) | SMN1; SMN2ALDH1A1LMNAMAPK1RAB9A | |
| SCHEMBL23840321 | 0.84 | MEN1 (0.39) | SMN1; SMN2ALDH1A1LMNAMAPK1RAB9A | |
| SCHEMBL23840413 | 0.84 | LMNA (0.48) | SMN1; SMN2ALDH1A1LMNAMAPK1GAA | |
| SCHEMBL23840501 | 0.83 | MEN1 (0.43) | SMN1; SMN2ALDH1A1LMNAMAPK1RAB9A | |
| SCHEMBL23840341 | 0.83 | KMT2A (0.46) | SMN1; SMN2ALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL25486018 | 0.82 | KDR (0.40) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL23840415 | 0.82 | MEN1 (0.45) | SMN1; SMN2ALDH1A1LMNAMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159509-A1 | PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159509-A1 | PYRIDINESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | TRAP1, PINK1, PPM1D | SMN1; SMN2 428/4885ALDH1A1 2592/4885LMNA 3370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.