Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.56 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.56 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | ACR | P10323 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23490200 | 0.88 | TNF (0.54) | TNFKLF5NOD1NPC1RAB9A | |
| SCHEMBL8363484 | 0.85 | USP2 (0.56) | NPC1RAB9AMAPTUSP2ALDH1A1 | |
| SCHEMBL25489139 | 0.83 | TNF (0.58) | TNFKLF5NOD1NPC1RAB9A | |
| SCHEMBL25489134 | 0.81 | TNF (0.47) | TNFKLF5NOD1NPC1RAB9A | |
| SCHEMBL25489140 | 0.79 | TNF (0.64) | TNFKLF5NOD1NPC1RAB9A | |
| SCHEMBL25489141 | 0.78 | TNF (0.58) | TNFKLF5NOD1NPC1RAB9A | |
| SCHEMBL29012462 | 0.76 | ALDH1A1 (0.51) | TNFKLF5NOD1NPC1RAB9A | |
| SCHEMBL26144285 | 0.76 | TNF (0.68) | TNFKLF5NOD1NPC1RAB9A | |
| SCHEMBL1788254 | 0.74 | MAPT (0.47) | NPC1RAB9AMAPTNPSR1LMNA | |
| SCHEMBL23490196 | 0.73 | LMNA (0.43) | TNFKLF5NOD1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11661418-B2 | MASP-2 inhibitors and methods of use | OMEROS CORPORATION (US) | 2023-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11661418-B2 | MASP-2 inhibitors and methods of use | MASP2, METAP2, SPINT2 | TNF 4805/4885KLF5 4655/4885NOD1 4176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.