Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.64 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.64 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.64 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23486912 | 0.85 | L3MBTL1 (0.67) | L3MBTL1ALDH1A1SMN1; SMN2TDP1MAPT | |
| SCHEMBL6793542 | 0.83 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1SMN1; SMN2TDP1MAPT | |
| SCHEMBL6793545 | 0.83 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1SMN1; SMN2TDP1MAPT | |
| SCHEMBL8363701 | 0.83 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1SMN1; SMN2TDP1MAPT | |
| SCHEMBL25489139 | 0.81 | TNF (0.58) | TNFKLF5NOD1NOD2L3MBTL1 | |
| SCHEMBL6794138 | 0.79 | HDAC3 (0.44) | TNFKLF5NOD1L3MBTL1ALDH1A1 | |
| SCHEMBL6794134 | 0.79 | HDAC3 (0.44) | TNFKLF5NOD1L3MBTL1ALDH1A1 | |
| SCHEMBL25489137 | 0.79 | TNF (0.56) | TNFKLF5NOD1NOD2L3MBTL1 | |
| SCHEMBL23490200 | 0.78 | TNF (0.54) | TNFKLF5NOD1NOD2L3MBTL1 | |
| SCHEMBL18320469 | 0.78 | KMT2A (0.69) | TNFKLF5NOD1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11661418-B2 | MASP-2 inhibitors and methods of use | OMEROS CORPORATION (US) | 2023-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11661418-B2 | MASP-2 inhibitors and methods of use | MASP2, METAP2, SPINT2 | TNF 4805/4885KLF5 4655/4885NOD1 4176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.