Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 9/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | ANTXR2 | P58335 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | PDIA4 | P13667 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26562238 | 0.96 | PAX8 (0.38) | PAX8KMT2AMEN1USP2POLB | |
| SCHEMBL27408610 | 0.92 | PAX8 (0.40) | PAX8KMT2AMEN1USP2POLB | |
| SCHEMBL12211060 | 0.92 | PTPN1 (0.37) | PAX8PTPN1LMNATSHRPRKCA | |
| SCHEMBL17552001 | 0.89 | TSHR (0.48) | PAX8KMT2AMEN1USP2POLB | |
| SCHEMBL17776090 | 0.89 | PTPN1 (0.39) | PTPN1 | |
| SCHEMBL9604484 | 0.88 | LMNA (0.38) | PAX8KMT2AMEN1USP2POLB | |
| SCHEMBL19929292 | 0.84 | PTPN1 (0.36) | KMT2APTPN1LMNATSHRCA12 | |
| SCHEMBL12920560 | 0.84 | PTPN1 (0.48) | KMT2AMEN1USP2POLBPTPN1 | |
| SCHEMBL15344765 | 0.84 | PAX8 (0.46) | PAX8KMT2AMEN1USP2POLB | |
| SCHEMBL14199422 | 0.83 | TSHR (0.48) | PAX8KMT2AMEN1USP2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11649459-B2 | Superoxide dismutase 1 (SOD1) iRNA compositions and methods of use thereof for treating or preventing superoxide dismutase 1-(SOD1-) associated neurodegenerative diseases | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11649459-B2 | Superoxide dismutase 1 (SOD1) iRNA compositions and methods of use thereof for treating or preventing superoxide dismutase 1-(SOD1-) associated neurodegenerative diseases | SOD1, SOD3, SMN1; SMN2 | PAX8 1858/4885KMT2A 2684/4885MEN1 4475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.