Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | LPL | P06858 | 1/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17518579 | 0.82 | PGR (0.30) | — | |
| SCHEMBL21623993 | 0.78 | REN (0.36) | GPR84LPLLIPGAR | |
| SCHEMBL29484287 | 0.76 | GPR84 (0.45) | GPR84LPLLIPG | |
| SCHEMBL21624054 | 0.74 | GPR84 (0.41) | GPR84LPLLIPG | |
| SCHEMBL14685262 | 0.74 | GSK3A (0.38) | LPLLIPG | |
| SCHEMBL21624063 | 0.72 | SLC6A4 (0.35) | LPLLIPG | |
| SCHEMBL29750587 | 0.72 | LPL (0.33) | LPLLIPG | |
| SCHEMBL25503944 | 0.72 | LPL (0.42) | LPLLIPG | |
| SCHEMBL25508375 | 0.72 | IDO1 (0.39) | GPR84LPLLIPG | |
| SCHEMBL21624189 | 0.72 | GPR84 (0.38) | GPR84LPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230144051-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230144051-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF KRAS | KRAS, NRAS, HRAS | GPR84 3564/4885ALDH1A1 1858/4885LMNA 2409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.