Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13522728 | 0.75 | CDC25B (0.49) | MAPTNPC1HTTKDM4EALDH1A1 | |
| SCHEMBL25516110 | 0.75 | KDM4E (0.41) | MAPTNPC1MAPK1HTTPRSS1 | |
| SCHEMBL24633560 | 0.75 | ALDH1A1 (0.44) | MAPTNPC1MAPK1HTTLRRK2 | |
| SCHEMBL22489533 | 0.75 | ALDH1A1 (0.60) | MAPTNPC1MAPK1KDM4EALDH1A1 | |
| SCHEMBL21938896 | 0.74 | PLAU (0.48) | MAPTNPC1MAPK1PRSS1PRSS3 | |
| SCHEMBL13211928 | 0.74 | ALOX15 (0.50) | MAPTNPC1MAPK1HTTLRRK2 | |
| SCHEMBL22920866 | 0.71 | ALDH1A1 (0.41) | MAPTNPC1MAPK1HTTALDH1A1 | |
| SCHEMBL22890834 | 0.71 | THRB (0.52) | MAPTLRRK2PRSS1PRSS2PRSS3 | |
| SCHEMBL25516265 | 0.71 | MAPT (0.43) | MAPTHTTLRRK2KDM4EALDH1A1 | |
| SCHEMBL23793382 | 0.70 | CA14 (0.40) | MAPTHTTLRRK2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078337-A1 | CDK8/19 DUAL INHIBITORS AND METHODS OF USE | INSILICO MEDICINE IP LIMITED (CN) | 2023-05-11 | — | — | WO | disclosed |