Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MPO | P05164 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | OGG1 | O15527 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25516110 | 0.81 | KDM4E (0.41) | MAPTBLMGFERKDM4EALDH1A1 | |
| SCHEMBL13522728 | 0.81 | CDC25B (0.49) | MAPTBLMGFERKDM4EALDH1A1 | |
| SCHEMBL24633560 | 0.80 | ALDH1A1 (0.44) | MAPTKDM4EALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL22489533 | 0.80 | ALDH1A1 (0.60) | MAPTKDM4EALDH1A1CA1CA2 | |
| SCHEMBL20217344 | 0.80 | ALDH1A1 (0.53) | KDM4EALDH1A1LMNAL3MBTL1HDAC1 | |
| SCHEMBL22452996 | 0.77 | LRRK2 (0.50) | MAPTKDM4ELMNAHDAC1HDAC6 | |
| SCHEMBL20217275 | 0.77 | KIT (0.53) | KDM4EALDH1A1CA2HDAC6HPGD | |
| SCHEMBL1252657 | 0.76 | MPO (0.54) | MAPTMPOCYP3A4BLMKDM5A | |
| SCHEMBL29803197 | 0.76 | MPO (0.54) | MAPTMPOCYP3A4BLMKDM5A | |
| SCHEMBL20217243 | 0.76 | KDM4E (0.51) | KDM4EALDH1A1LMNAHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078337-A1 | CDK8/19 DUAL INHIBITORS AND METHODS OF USE | INSILICO MEDICINE IP LIMITED (CN) | 2023-05-11 | — | — | WO | disclosed |