Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 12/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9295951 | 0.80 | MEN1 (0.45) | PDE4BPDE4DTDP1KMT2AMEN1 | |
| SCHEMBL12635490 | 0.75 | GSK3B (0.45) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL31714994 | 0.74 | TSHR (0.57) | TDP1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL3735853 | 0.73 | TSHR (0.63) | TDP1KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL13077554 | 0.73 | TSHR (0.63) | TDP1KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL3735855 | 0.73 | TSHR (0.63) | TDP1KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL31714667 | 0.71 | TSHR (0.39) | TDP1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL10573552 | 0.71 | KMT2A (0.36) | TDP1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL27757617 | 0.67 | ALDH1A1 (0.46) | PDE4BPDE4DTDP1KMT2AMEN1 | |
| SCHEMBL25522503 | 0.65 | ALDH1A1 (0.36) | PDE4BPDE4DKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-06-06 | — | — | US | disclosed |
| US-11666577-B2 | MLKL inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | MLKL, CMKLR1, PCSK9 | PDE4B 1621/4885PDE4D 2206/4885TDP1 1470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.