Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2590362 | 0.82 | HDAC1 (0.44) | MAPTKMT2AL3MBTL1MEN1GAA | |
| SCHEMBL16491994 | 0.82 | HDAC8 (0.50) | MAPTKMT2AL3MBTL1MEN1GAA | |
| SCHEMBL9822953 | 0.82 | KMT2A (0.59) | MAPTMAPK1KMT2APKML3MBTL1 | |
| SCHEMBL992446 | 0.82 | HCAR3 (0.68) | MAPTKMT2APKML3MBTL1HCAR3 | |
| SCHEMBL28644813 | 0.81 | KMT2A (0.58) | MAPTKMT2APKMHCAR3MEN1 | |
| SCHEMBL15687598 | 0.80 | POLB (0.61) | MAPTKMT2APKML3MBTL1HCAR3 | |
| SCHEMBL30590597 | 0.80 | KMT2A (0.59) | MAPTMAPK1KMT2APKML3MBTL1 | |
| SCHEMBL29117538 | 0.80 | KMT2A (0.59) | MAPTMAPK1KMT2APKML3MBTL1 | |
| SCHEMBL10732354 | 0.79 | HCAR3 (0.55) | MAPTKMT2APKMHCAR3NPC1 | |
| SCHEMBL28126128 | 0.78 | LMNA (0.60) | MAPTKMT2AHCAR3MEN1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296748-B2 | Pyridinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-03-29 | — | — | US | disclosed |
| US-20150246919-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INT (DE) | 2015-09-03 | — | — | US | disclosed |
| US-20150051208-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-19 | — | — | US | disclosed |
| WO-2015022332-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-19 | — | — | WO | disclosed |
| WO-2011124638-A1 | PIMOBENDAN MANUFACTURING PROCESS | NOVARTIS AG (CH) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011124638-A1 | PIMOBENDAN MANUFACTURING PROCESS | NOVARTIS AG (CH) | 2011-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051208-A1 | PYRIDINONES | MKI67, XDH, CDK6 | MAPT 4084/4885MAPK1 948/4885KMT2A 3495/4885 |
| US-20150246919-A1 | PYRIDINONES | MKI67, XDH, CDK6 | MAPT 4084/4885MAPK1 948/4885KMT2A 3495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.