Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25527205 | 0.80 | ALDH1A1 (0.41) | PGK1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6995100 | 0.74 | ALDH1A1 (0.42) | KDM4EPOLBALDH1A1MEN1NPC1 | |
| SCHEMBL9881010 | 0.71 | ALDH1A3 (0.36) | ALDH1A1GAA | |
| SCHEMBL28962063 | 0.68 | KMT2A (0.48) | FGFR1PSMB5KDM4EKMT2ANPSR1 | |
| SCHEMBL30600413 | 0.67 | ALDH1A1 (0.50) | KDM4EPOLBALDH1A1MEN1NPC1 | |
| SCHEMBL10494663 | 0.67 | ALDH1A1 (0.50) | KDM4EPOLBALDH1A1MEN1NPC1 | |
| SCHEMBL13681886 | 0.67 | RXFP1 (0.37) | KDM4EPOLBALDH1A1MEN1NPC1 | |
| SCHEMBL11971651 | 0.67 | KDM4E (0.48) | KDM4EPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL3263288 | 0.67 | ACP1 (0.52) | FGFR1KDM4EALDH1A1NPC1NPSR1 | |
| SCHEMBL13681867 | 0.67 | RXFP1 (0.41) | KDM4EPOLBALDH1A1MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159510-A1 | NOVEL PRMT5 INHIBITORS | AMGEN INC. (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159510-A1 | NOVEL PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | PGK1 905/4885FGFR1 2558/4885SRC 627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.