Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25526115 | 0.82 | CYP1A2 (0.37) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL25527358 | 0.80 | PGK1 (0.41) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL9881010 | 0.76 | ALDH1A3 (0.36) | ALDH1A1MAPTGAAALDH1A3 | |
| SCHEMBL11971651 | 0.75 | KDM4E (0.48) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL25522111 | 0.73 | CYP1A2 (0.40) | ALDH1A1KDM4EHPGDMAPTTSHR | |
| Hydrochloric Acid SCHEMBL5873588 | 0.70 | MCHR1 (0.56) | ALDH1A1MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL6641202 | 0.70 | ALDH1A1 (0.45) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL11971520 | 0.69 | PDE10A (0.50) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL11971854 | 0.68 | ALDH1A1 (0.52) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL29045541 | 0.68 | ELANE (0.44) | ALDH1A1KDM4EHPGDMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159510-A1 | NOVEL PRMT5 INHIBITORS | AMGEN INC. (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159510-A1 | NOVEL PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT3 | ALDH1A1 3191/4885KDM4E 45/4885HSD17B10 2125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.