Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | ACACB | O00763 | 8/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | EBP | Q15125 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25531149 | 0.88 | SIGMAR1 (0.47) | SIGMAR1ACACBHTTTP53TSHR | |
| SCHEMBL25531107 | 0.84 | SIGMAR1 (0.50) | SIGMAR1ACACBTP53TSHREBP | |
| SCHEMBL25541885 | 0.84 | SIGMAR1 (0.50) | SIGMAR1ACACBTP53TSHREBP | |
| SCHEMBL25531103 | 0.84 | SIGMAR1 (0.50) | SIGMAR1ACACBTP53TSHREBP | |
| SCHEMBL25541872 | 0.83 | SIGMAR1 (0.49) | SIGMAR1ACACBTP53TSHREBP | |
| SCHEMBL25541877 | 0.83 | SIGMAR1 (0.49) | SIGMAR1ACACBTP53TSHREBP | |
| SCHEMBL23481849 | 0.81 | SIGMAR1 (0.87) | SIGMAR1TSHRKCNH2SLC6A4 | |
| SCHEMBL12404709 | 0.79 | SIGMAR1 (0.62) | SIGMAR1ACACBHTTSLC6A4 | |
| SCHEMBL7120636 | 0.76 | SIGMAR1 (0.61) | SIGMAR1ACACBTP53TSHREBP | |
| SCHEMBL25541899 | 0.76 | SLC6A4 (0.55) | SIGMAR1ACACBTP53TSHREBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159491-A1 | Antimicrobial Compounds and Methods | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159491-A1 | Antimicrobial Compounds and Methods | MPO, NISCH, RPN2 | SIGMAR1 1380/4885ACACB 2485/4885HTT 3996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.