Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12491068 | 0.87 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL170770 | 0.84 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL10238970 | 0.83 | ALDH1A1 (0.61) | ALDH1A1LMNAMEN1KMT2AMAPT | |
| SCHEMBL4509900 | 0.81 | ALDH1A1 (0.50) | SIGMAR1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL11283585 | 0.81 | SIGMAR1 (0.48) | SIGMAR1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL4105884 | 0.80 | L3MBTL1 (0.49) | SIGMAR1ALDH1A1MAPTL3MBTL1ATM | |
| SCHEMBL4523309 | 0.80 | SIGMAR1 (0.56) | SIGMAR1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL22864682 | 0.80 | L3MBTL1 (0.49) | SIGMAR1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL30751751 | 0.80 | L3MBTL1 (0.49) | SIGMAR1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL9566441 | 0.80 | SIGMAR1 (0.56) | SIGMAR1ALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012030685-A2 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |