Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16053764 | 0.99 | L3MBTL1 (0.48) | L3MBTL1ATMALDH1A1SIGMAR1KDM4E | |
| SCHEMBL30751751 | 0.98 | L3MBTL1 (0.49) | L3MBTL1ATMALDH1A1SIGMAR1KDM4E | |
| SCHEMBL4509900 | 0.95 | ALDH1A1 (0.50) | L3MBTL1ATMALDH1A1SIGMAR1KDM4E | |
| SCHEMBL24729554 | 0.90 | ALDH1A1 (0.42) | L3MBTL1ATMALDH1A1SIGMAR1KDM4E | |
| SCHEMBL30751712 | 0.90 | SIGMAR1 (0.48) | L3MBTL1ATMALDH1A1SIGMAR1CYP3A4 | |
| SCHEMBL27329178 | 0.87 | ALDH1A1 (0.47) | L3MBTL1ATMALDH1A1SIGMAR1KDM4E | |
| SCHEMBL6356789 | 0.87 | CYP2D6 (0.46) | ALDH1A1KDM4ECYP3A4CYP2D6MEN1 | |
| SCHEMBL21685887 | 0.85 | SIGMAR1 (0.47) | L3MBTL1ATMALDH1A1SIGMAR1KDM4E | |
| SCHEMBL4105884 | 0.84 | L3MBTL1 (0.49) | L3MBTL1ATMALDH1A1SIGMAR1KDM4E | |
| SCHEMBL9566495 | 0.84 | KDM4E (0.53) | L3MBTL1ATMALDH1A1SIGMAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. | 2022-12-08 | — | — | US | disclosed |
| WO-2021000935-A1 | HPK1 INHIBITORS AND USES THEREOF | QILU REGOR THERAPEUTICS INC. (CN) | 2021-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | HIPK1, SIK1, PGK1 | L3MBTL1 2199/4885ATM 924/4885ALDH1A1 3740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.