Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | SNCA | P37840 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA3 | P07451 | 1/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
| ▸ | CA5A | P35218 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2553988 | 1.00 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL30656553 | 1.00 | KDM4E (0.69) | KDM4EALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL2408521 | 0.93 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL2408525 | 0.93 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL23805172 | 0.91 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL14342653 | 0.90 | FDPS (0.61) | KDM4EALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL9553571 | 0.90 | FDPS (0.61) | KDM4EALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL17529412 | 0.88 | KMT2A (0.56) | KDM4EALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL22770082 | 0.88 | KDM4E (0.57) | KDM4EALDH1A1HPGDHSD17B10ALOX15 | |
| SCHEMBL23665036 | 0.87 | KMT2A (0.54) | KDM4EALDH1A1HPGDHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925755-B1 | NEUROPROTECTIVE AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | UNIV WAYNE STATE (US) | 2021-09-08 | — | — | EP | disclosed |
| US-10874669-B2 | Neuroprotective agents for treatment of neurodegenerative diseases | WAYNE STATE UNIVERSITY (US) | 2020-12-29 | — | — | US | disclosed |
| US-20190076426-A1 | NEUROPROTECTIVE AGENTS FOR TREATMENT OF NEURODEGENERATIVE DISEASES | WAYNE STATE UNIVERSITY | 2019-03-14 | — | — | US | disclosed |
| US-20190038622-A1 | NEUROPROTECTIVE AGENTS FOR TREATMENT OF NEURODEGENERATIVE DISEASES | WAYNE STATE UNIVERSITY | 2019-02-07 | — | — | US | disclosed |
| US-10125127-B2 | Neuroprotective agents for treatment of neurodegenerative diseases | WAYNE STATE UNIVERSITY (US) | 2018-11-13 | — | — | US | disclosed |
| US-20150299180-A1 | NEUROPROTECTIVE AGENTS FOR TREATMENT OF NEURODEGENERATIVE DISEASES | WAYNE STATE UNIVERSITY (US) | 2015-10-22 | — | — | US | disclosed |
| US-8637674-B2 | Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2014-01-28 | — | — | US | disclosed |
| EP-2556062-A1 | AMIDE DERIVATIVES OF CINNAMIC, FERULIC AND AVENALUMIC SERIES, PROCESS FOR PREPARING SAME AND COSMETIC COMPOSITIONS CONTAINING SAME | Produits Chimiques Auxiliaires et de Synthese (FR) | 2013-02-13 | — | — | EP | disclosed |
| US-20120232117-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION (KR) | 2012-09-13 | — | — | US | disclosed |
| WO-2011124844-A1 | AMIDE DERIVATIVES OF CINNAMIC, FERULIC AND AVENALUMIC SERIES, PROCESS FOR PREPARING SAME AND COSMETIC COMPOSITIONS CONTAINING SAME | PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE (FR) | 2011-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299180-A1 | NEUROPROTECTIVE AGENTS FOR TREATMENT OF NEURODEGENERATIVE DISEASES | RTN4, NR4A1, NR4A3 | KDM4E 1641/4885ALDH1A1 1123/4885HPGD 1787/4885 |
| US-20190076426-A1 | NEUROPROTECTIVE AGENTS FOR TREATMENT OF NEURODEGENERATIVE DISEASES | SMN1; SMN2, PARK7, SNCA | KDM4E 3307/4885ALDH1A1 1481/4885HPGD 1216/4885 |
| US-20190038622-A1 | NEUROPROTECTIVE AGENTS FOR TREATMENT OF NEURODEGENERATIVE DISEASES | SMN1; SMN2, PARK7, SNCA | KDM4E 3307/4885ALDH1A1 1481/4885HPGD 1216/4885 |
| US-10125127-B2 | Neuroprotective agents for treatment of neurodegenerative diseases | RTN4, NR4A1, NR4A3 | KDM4E 1641/4885ALDH1A1 1123/4885HPGD 1787/4885 |
| US-10874669-B2 | Neuroprotective agents for treatment of neurodegenerative diseases | SMN1; SMN2, PARK7, SNCA | KDM4E 3307/4885ALDH1A1 1481/4885HPGD 1216/4885 |
| US-20120232117-A1 | PYRAZOLE DERIVATIVES, PREPARATION METHOD THEREOF, AND COMPOSITION FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS CONTAINING SAME | PTH1R, VDR, SOST | KDM4E 1561/4885ALDH1A1 2869/4885HPGD 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.