Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2322786 | 0.78 | LDHA (0.54) | PTPN1AXLPIK3C3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3528772 | 0.76 | LDHA (0.53) | PTPN1AXLPIK3C3ALDH1A1 | |
| SCHEMBL25529069 | 0.75 | L3MBTL1 (0.47) | PTPN1EGLN1KDM4ETDP1POLB | |
| SCHEMBL30174268 | 0.75 | L3MBTL1 (0.47) | PTPN1EGLN1KDM4ETDP1POLB | |
| SCHEMBL18304661 | 0.73 | KAT6A (0.62) | PTPN1KEAP1KDM4ETDP1POLB | |
| SCHEMBL22126658 | 0.72 | PTPN1 (0.60) | PTPN1KEAP1 | |
| SCHEMBL1173724 | 0.72 | EGLN1 (0.57) | PTPN1AXLKEAP1EGLN1KDM4E | |
| SCHEMBL17729031 | 0.71 | KEAP1 (0.64) | PTPN1AXLKEAP1EGLN1KDM4E | |
| SCHEMBL27603195 | 0.71 | MCL1 (0.61) | AXLPIK3C3KDM4EMAPTALDH1A1 | |
| SCHEMBL11064733 | 0.71 | MAP4K4 (0.50) | PIK3C3EGLN1KDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230150997-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. | 2023-05-18 | — | — | US | disclosed |
| US-20230150997-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. | 2023-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230150997-A1 | EIF4E INHIBITORS AND USES THEREOF | EIF4E, EIF4EBP1, EIF4A1 | PTPN1 2774/4885AXL 3024/4885KEAP1 1548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.