Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 9/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25551292 | 0.82 | RIPK1 (0.48) | MAPTHPGDRIPK1BRD4CYP17A1 | |
| SCHEMBL25551278 | 0.78 | HDAC6 (0.44) | MAPTHPGDRIPK1HDAC6MEN1 | |
| SCHEMBL20095590 | 0.73 | RIPK1 (0.43) | MAPTHPGDRIPK1BRD4DRD4 | |
| SCHEMBL10238795 | 0.71 | CHRNA7 (0.57) | CHRNA7CYP1A2 | |
| SCHEMBL6845140 | 0.71 | CHRNA7 (0.57) | CHRNA7CYP1A2 | |
| SCHEMBL23913768 | 0.71 | RIPK1 (0.47) | RIPK1MEN1BLMKMT2ASRD5A1 | |
| SCHEMBL13502655 | 0.70 | DRD4 (0.48) | MAPTHPGDRIPK1BRD4DRD4 | |
| SCHEMBL25556401 | 0.70 | DRD4 (0.48) | MAPTHPGDRIPK1BRD4DRD4 | |
| SCHEMBL24094029 | 0.70 | RIPK1 (0.43) | MAPTHPGDRIPK1 | |
| SCHEMBL26493269 | 0.69 | SRD5A1 (0.41) | MAPTHPGDRIPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159508-A1 | INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159508-A1 | INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE | RIPK1, RIPK2, RIPK4 | CHRNA7 1861/4885MAPT 577/4885HPGD 3055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.