Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 5/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 2/20 | 0.32 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | SI | P14410 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3279246 | 0.81 | PKM (0.38) | KEAP1HCAR3HPGDPOLBMGAM | |
| SCHEMBL19848287 | 0.81 | KEAP1 (0.47) | KEAP1SLC9A1HCAR3CYP19A1CYP11B1 | |
| SCHEMBL25881417 | 0.79 | HCAR3 (0.41) | KEAP1SLC9A1HCAR3CYP19A1RAB9A | |
| SCHEMBL25556243 | 0.77 | KEAP1 (0.47) | KEAP1SLC9A1HCAR3CYP19A1CYP11B1 | |
| SCHEMBL25881312 | 0.76 | HCAR3 (0.41) | KEAP1SLC9A1HCAR3CYP19A1RAB9A | |
| SCHEMBL25221496 | 0.75 | KEAP1 (0.41) | KEAP1SLC9A1HCAR3CYP19A1CYP11B1 | |
| SCHEMBL8562891 | 0.73 | KEAP1 (0.47) | KEAP1SLC9A1HCAR3CYP19A1CYP11B1 | |
| SCHEMBL10777056 | 0.71 | KEAP1 (0.41) | KEAP1SLC9A1HCAR3CYP19A1CYP11B1 | |
| SCHEMBL11532299 | 0.71 | KDM4E (0.49) | RAB9ANPC1MEN1KMT2AKDM4E | |
| SCHEMBL25210239 | 0.69 | PGK1 (0.44) | HCAR3RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |