Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 7/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19496039 | 0.90 | CYP11B1 (0.55) | CYP11B1CYP11B2CYP19A1CYP1A2CYP17A1 | |
| SCHEMBL25017649 | 0.87 | CYP11B2 (0.49) | CYP11B1CYP11B2CYP19A1CYP1A2CYP17A1 | |
| SCHEMBL12045381 | 0.81 | ACVRL1 (0.43) | CYP11B1CYP11B2CYP19A1CYP1A2CYP17A1 | |
| SCHEMBL23563044 | 0.80 | SIGMAR1 (0.41) | CYP11B1CYP11B2CYP17A1SIGMAR1BMPR1B | |
| SCHEMBL19495406 | 0.76 | CYP11B1 (0.58) | CYP11B1CYP11B2CYP19A1CYP1A2CYP17A1 | |
| SCHEMBL29946500 | 0.75 | MEN1 (0.50) | CYP1A2 | |
| SCHEMBL678115 | 0.75 | MEN1 (0.50) | CYP1A2 | |
| SCHEMBL25585039 | 0.74 | GRM5 (0.38) | CYP11B1CYP11B2CYP19A1CYP1A2CYP17A1 | |
| SCHEMBL16998410 | 0.74 | SIGMAR1 (0.48) | SIGMAR1CHRNB2CHRNA4 | |
| SCHEMBL25585024 | 0.73 | CYP19A1 (0.49) | CYP11B1CYP11B2CYP19A1CYP1A2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159508-A1 | INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159508-A1 | INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE | RIPK1, RIPK2, RIPK4 | CYP11B1 4431/4885CYP11B2 4704/4885CYP19A1 4476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.