Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 2/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838629 | 0.88 | CAMK2A (0.68) | CXCL8SLC6A2SLC6A4CAMK2ASRD5A2 | |
| Hydrogen Sulfide SCHEMBL28780977 | 0.86 | CAMK2A (0.66) | CXCL8SLC6A2SLC6A4CAMK2ASRD5A2 | |
| SCHEMBL11335218 | 0.85 | CXCL8 (0.59) | CXCL8CAMK2ASRD5A2CHRM1FFAR1 | |
| SCHEMBL10561756 | 0.85 | CXCL8 (0.69) | CXCL8SLC6A4CAMK2ACHRM1FFAR1 | |
| SCHEMBL2353783 | 0.85 | CAMK2A (0.69) | CXCL8CAMK2ACHRM1FFAR1AKR1B1 | |
| SCHEMBL22654316 | 0.85 | LMNA (0.57) | CXCL8SLC6A2SLC6A4SLC6A3CAMK2A | |
| SCHEMBL2560429 | 0.84 | HSD17B10 (0.51) | SLC6A2SLC6A4SLC6A3CAMK2ASRD5A2 | |
| SCHEMBL872958 | 0.84 | CXCL8 (0.67) | CXCL8SLC6A2SLC6A4SLC6A3CAMK2A | |
| Ammonia Solution, Strong SCHEMBL872909 | 0.83 | CHRM1 (0.65) | CXCL8SLC6A2SLC6A4SLC6A3CAMK2A | |
| SCHEMBL11097326 | 0.82 | CXCL8 (0.79) | CXCL8CAMK2ACHRM1AKR1B1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |