SCHEMBL838629

SCHEMBL838629

O=C(O)Cc1ccccc1Oc1ccccc1

nearest known ligand 0.68

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CAMK2A Q9UQM7 2/20 0.68
CXCL8 P10145 2/20 0.67
CHRM1 P11229 1/20 0.58
HRH1 P35367 1/20 0.55
FFAR1 O14842 1/20 0.54
AKR1B1 P15121 1/20 0.53
RIPK1 Q13546 1/20 0.53
SLC6A2 P23975 1/20 0.53
SLC6A4 P31645 1/20 0.53
PTGDR2 Q9Y5Y4 1/20 0.51
CTNNB1 P35222 1/20 0.50
FFAR4 Q5NUL3 1/20 0.49
PPARA Q07869 1/20 0.49
GAA P10253 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
SRD5A2 P31213 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrogen Sulfide SCHEMBL28780977 0.98 CAMK2A (0.66) CAMK2ACXCL8CHRM1HRH1FFAR1
SCHEMBL9288801 0.92 CAMK2A (0.63) CAMK2ACXCL8CHRM1HRH1FFAR1
SCHEMBL8969152 0.91 CAMK2A (0.62) CAMK2ACXCL8CHRM1HRH1FFAR1
SCHEMBL11097326 0.90 CXCL8 (0.79) CAMK2ACXCL8CHRM1AKR1B1L3MBTL1
SCHEMBL2353783 0.90 CAMK2A (0.69) CAMK2ACXCL8CHRM1HRH1FFAR1
SCHEMBL11335218 0.90 CXCL8 (0.59) CAMK2ACXCL8CHRM1FFAR1AKR1B1
SCHEMBL10561756 0.90 CXCL8 (0.69) CAMK2ACXCL8CHRM1HRH1FFAR1
SCHEMBL2555874 0.88 CXCL8 (0.58) CAMK2ACXCL8CHRM1HRH1FFAR1
SCHEMBL872958 0.88 CXCL8 (0.67) CAMK2ACXCL8CHRM1FFAR1SLC6A2
Ammonia Solution, Strong SCHEMBL872909 0.87 CHRM1 (0.65) CAMK2ACXCL8CHRM1FFAR1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 248 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7199259-B2 Resolution of α-(phenoxy)phenylacetic acid derivatives METABOLEX, INC. (US) 2007-04-03 US claimed
EP-1635809-A4 RESOLUTION OF ALPHA-(PHENOXY)PHENYLACETIC ACID DERIVATIVES METABOLEX INC (US) 2006-09-27 EP claimed
EP-1635809-A1 RESOLUTION OF ALPHA-(PHENOXY)PHENYLACETIC ACID DERIVATIVES Metabolex, Inc. (US) 2006-03-22 EP claimed
US-20050033084-A1 Resolution of alpha-(phenoxy)phenylacetic acid derivatives METABOLEX, INC. (US) 2005-02-10 US claimed
WO-2004112774-A1 RESOLUTION OF α-(PHENOXY)PHENYLACETIC ACID DERIVATIVES METABOLEX, INC. (US) 2004-12-29 WO claimed
US-6469195-B1 SUITABLE FOR USE AS CROP PROTECTION AGENTS AGAINST HARMFUL FUNGI BASF AKTIENGESELLSCHAFT (DE) 2002-10-22 US claimed
JP-2001501449-A 2001-02-06 JP claimed
EP-0873334-A1 PROCESS FOR THE PREPARATION OF AN ENDOTHELIN ANTAGONIST Merck & Co., Inc. (a New Jersey corp.) (US) 1998-10-28 EP claimed
EP-0868535-A2 METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES Rapigene, Inc. (US) 1998-10-07 EP claimed
US-5688974-A Process for the preparation of an endothelin antagonist MERCK & CO., INC. (US) 1997-11-18 US claimed
WO-1997027331-A9 METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES 1997-10-09 WO claimed
WO-1997027331-A2 METHODS AND COMPOSITIONS FOR DETERMINING THE SEQUENCE OF NUCLEIC ACID MOLECULES RAPIGENE, INC. (US) 1997-07-31 WO claimed
WO-1997021700-A1 PROCESS FOR THE PREPARATION OF AN ENDOTHELIN ANTAGONIST MERCK & CO., INC. (US) 1997-06-19 WO claimed
EP-0278176-B1 Compounds having antitumour and antibacterial properties WARNER LAMBERT CO (US) 1994-03-09 EP claimed
EP-0278176-A2 Compounds having antitumour and antibacterial properties WARNER-LAMBERT COMPANY (US) 1988-08-17 EP claimed
JP-54122284-A None JP disclosed
US-12458624-B2 Deuterium-enriched substituted phenoxyphenyl acetic acids and acylsulfonamides DHANOA DALJIT SINGH (US) 2025-11-04 US disclosed
US-4310544-A Hydroxyacetic acid derivatives with anti-arthritic properties IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-01-12 US disclosed
EP-0009306-A1 Anti-arthritic hydroxyacetic acid derivatives, pharmaceutical compositions thereof, and processes for their manufacture IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1980-04-02 EP disclosed
JP-S54122284-A DIBENZB,FOXEPIN DERIVATIVE DAINIPPON PHARMACEUT CO LTD 1979-09-21 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050033084-A1 Resolution of alpha-(phenoxy)phenylacetic acid derivatives PAH, PDGFA, PDGFRA CAMK2A 2205/4885CXCL8 4536/4885CHRM1 611/4885
US-12458624-B2 Deuterium-enriched substituted phenoxyphenyl acetic acids and acylsulfonamides AGTR2, AGTR1, EDNRA CAMK2A 1505/4885CXCL8 4697/4885CHRM1 649/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.