SCHEMBL25564753

SCHEMBL25564753

O=C(O)C(NC(=O)C(F)(F)F)C1CCCCC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.38
PDK1 Q15118 1/20 0.38
PDK2 Q15119 1/20 0.38
PDK3 Q15120 1/20 0.38
PDK4 Q16654 1/20 0.38
CNR1 P21554 1/20 0.38
CNR2 P34972 1/20 0.38
PYGL P06737 6/20 0.36
PRSS1 P07477 2/20 0.35
TMPRSS15 P98073 2/20 0.35
MMP2 P08253 3/20 0.35
MMP1 P03956 1/20 0.35
MMP3 P08254 1/20 0.35
MMP7 P09237 1/20 0.35
MMP13 P45452 1/20 0.35
EPHX1 P07099 1/20 0.34
PKM P14618 1/20 0.34
CA12 O43570 2/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25076151 0.95 PKM (0.35) DPP4PDK1PDK2PDK3PDK4
SCHEMBL25564751 0.81 TP53 (0.42) PDK1PDK2PDK3PDK4MMP2
SCHEMBL3416246 0.81 MMP1 (0.49) PDK1PDK2PDK3PDK4MMP2
SCHEMBL8283711 0.80 PDK1 (0.34) DPP4PDK1PDK2PDK3PDK4
SCHEMBL14074440 0.79 PDK1 (0.33) DPP4PDK1PDK2PDK3PDK4
SCHEMBL9171597 0.79 PYGL (0.41) DPP4CNR1CNR2PYGLMMP2
SCHEMBL25421475 0.77
SCHEMBL31203641 0.77 PYGL (0.35) PDK1PDK2PDK3PDK4CNR1
SCHEMBL3107097 0.76 CA12 (0.54) PDK1PDK2PDK3PDK4CNR2
SCHEMBL19075636 0.76 ALDH1A1 (0.37) CNR1CNR2PYGLPRSS1TMPRSS15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023093834-A1 PYRROLIDINE ANTIVIRAL COMPOUND 先声再明医药有限公司 2023-06-01 WO disclosed