Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2679197 | 0.79 | NPC1 (0.47) | MEN1KMT2APOLBNPC1MAPT | |
| SCHEMBL1163789 | 0.79 | NPC1 (0.49) | MEN1KMT2APOLBNPC1MAPT | |
| SCHEMBL6508869 | 0.79 | MEN1 (0.82) | MEN1KMT2APOLBNPC1MAPT | |
| SCHEMBL2666244 | 0.79 | MEN1 (0.59) | MEN1KMT2APOLBNPC1MAPT | |
| SCHEMBL10594578 | 0.78 | RAB9A (0.50) | MEN1KMT2ANPC1MAPTRAB9A | |
| Bromide SCHEMBL30271836 | 0.78 | NPC1 (0.47) | MEN1KMT2APOLBNPC1MAPT | |
| SCHEMBL2118292 | 0.77 | MEN1 (0.47) | MEN1KMT2ANPC1MAPTRAB9A | |
| SCHEMBL13662705 | 0.76 | MEN1 (0.56) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL12441003 | 0.76 | MEN1 (0.56) | MEN1KMT2APOLBNPC1MAPT | |
| SCHEMBL27945271 | 0.76 | KMT2A (0.56) | MEN1KMT2APOLBNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |