Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1163789 | 0.83 | NPC1 (0.49) | NPC1L3MBTL1POLBMEN1KMT2A | |
| Bromide SCHEMBL30271836 | 0.81 | NPC1 (0.47) | NPC1L3MBTL1POLBMEN1KMT2A | |
| SCHEMBL6543819 | 0.79 | MAPT (0.48) | NPC1L3MBTL1MAPTLMNAPDGFRB | |
| SCHEMBL2556630 | 0.79 | MEN1 (0.66) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL8030882 | 0.79 | TRPV3 (0.51) | — | |
| SCHEMBL20743671 | 0.78 | GABRA1 (0.36) | NPC1MEN1KMT2AMAPTATM | |
| SCHEMBL8501004 | 0.77 | NPC1 (0.70) | NPC1L3MBTL1RXFP1POLBMEN1 | |
| SCHEMBL7444977 | 0.76 | KMT2A (0.72) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL11166932 | 0.76 | CDK5 (0.42) | NPC1MAPTPDGFRBPDGFRASMN1; SMN2 | |
| SCHEMBL27681382 | 0.76 | MKNK1 (0.49) | MEN1KMT2AGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017038873-A1 | UREA DERIVATIVE AND USE THEREFOR | 東レ株式会社 | 2017-03-09 | — | — | WO | disclosed |
| US-8173807-B2 | Pyridine, pyrimidine and pyrazine derivatives as GPCR agonists | PROSIDION LIMITED (GB) | 2012-05-08 | — | — | US | disclosed |
| EP-1838698-B1 | PYRIMIDINE DERIVATIVES AS GPCR AGONISTS | PROSIDION LTD (GB) | 2010-09-01 | — | — | EP | disclosed |
| US-20100035897-A1 | Pyridine, pyrimidine and pyrazine derivatives as gpcr agonists | PROSIDION LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| EP-1838698-A1 | PYRIMIDINE DERIVATIVES AS GPCR AGONISTS | Prosidion Limited (GB) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006070208-A1 | PYRIDINE, PYRIMIDINE AND PYRAZINE DERIVATIVES AS GPCR AGONISTS | PROSIDION LTD. (GB) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035897-A1 | Pyridine, pyrimidine and pyrazine derivatives as gpcr agonists | GPR119, GPR52, GPR65 | NPC1 2333/4885L3MBTL1 4020/4885RXFP1 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.