Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22021683 | 0.87 | NAMPT (0.32) | EPHX2CNR1NPC1 | |
| SCHEMBL12793200 | 0.83 | EPHX2 (0.36) | EPHX2CNR1ALDH1A1SIGMAR1BCHE | |
| SCHEMBL21376559 | 0.83 | EPHX2 (0.36) | EPHX2CNR1ALDH1A1HPGDSIGMAR1 | |
| SCHEMBL13407584 | 0.83 | CHRM2 (0.33) | KDM5AKDM4CDNM1 | |
| SCHEMBL21341604 | 0.83 | LMNA (0.34) | ALDH1A1NPC1 | |
| SCHEMBL12209818 | 0.80 | ALDH1A1 (0.42) | EPHX2CNR1ALDH1A1HPGDKDM5A | |
| SCHEMBL13964304 | 0.79 | ALDH1A1 (0.50) | EPHX2CNR1ALDH1A1KDM5AKDM4C | |
| SCHEMBL22021691 | 0.79 | EPHX2 (0.50) | EPHX2CNR1ALDH1A1KDM5AKDM4C | |
| SCHEMBL20129897 | 0.78 | ALDH1A1 (0.36) | EPHX2CNR1ALDH1A1HPGDKDM5A | |
| SCHEMBL17615113 | 0.78 | NPC1 (0.31) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230158157-A1 | POTENT AND SELECTIVE DEGRADERS OF ALK | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230158157-A1 | POTENT AND SELECTIVE DEGRADERS OF ALK | ALK, ERBB2, PDGFRB | EPHX2 1951/4885CNR1 1114/4885ALDH1A1 2106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.