Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25568576 | 1.00 | ALDH1A1 (0.44) | ALDH1A1TDP1KDM4EGAAHPGD | |
| SCHEMBL19525730 | 1.00 | ALDH1A1 (0.44) | ALDH1A1TDP1KDM4EGAAHPGD | |
| SCHEMBL24731320 | 0.91 | ALDH1A1 (0.39) | ALDH1A1TDP1KDM4EGAAHPGD | |
| SCHEMBL25779493 | 0.81 | CYP1A2 (0.37) | ALDH1A1TDP1KDM4EGAAHPGD | |
| SCHEMBL21701429 | 0.81 | CYP1A2 (0.37) | ALDH1A1TDP1KDM4EGAAHPGD | |
| SCHEMBL18781636 | 0.81 | ALDH1A1 (0.34) | ALDH1A1TDP1KDM4EGAAHPGD | |
| SCHEMBL25779438 | 0.81 | CYP1A2 (0.37) | ALDH1A1TDP1KDM4EGAAHPGD | |
| SCHEMBL8780315 | 0.81 | KDM4E (0.47) | ALDH1A1KDM4EGAAHPGDSMN1; SMN2 | |
| SCHEMBL134119 | 0.81 | ALDH1A1 (0.46) | ALDH1A1TDP1KDM1AMAOB | |
| SCHEMBL1933555 | 0.79 | ALDH1A1 (0.44) | ALDH1A1TDP1KDM1AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159517-A1 | CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME LLC (US) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159517-A1 | CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | TCOF1, SLC10A2, PAM | ALDH1A1 4179/4885TDP1 3270/4885KDM4E 4015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.