Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.75 |
| ▸ | DRD1 | P21728 | 5/20 | 0.75 |
| ▸ | HTR1A | P08908 | 4/20 | 0.75 |
| ▸ | TH | P07101 | 4/20 | 0.75 |
| ▸ | DRD3 | P35462 | 4/20 | 0.75 |
| ▸ | HTR2A | P28223 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | GMNN | O75496 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | GFER | P55789 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.61 |
| ▸ | DRD5 | P21918 | 1/20 | 0.61 |
| ▸ | RGS12 | O14924 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12284669 | 1.00 | DRD2 (0.75) | DRD2DRD1HTR1ATHDRD3 | |
| SCHEMBL15180898 | 0.88 | DRD2 (0.87) | DRD2DRD1HTR1ATHDRD3 | |
| SCHEMBL1203699 | 0.86 | DRD2 (1.00) | DRD2DRD1HTR1ATHDRD3 | |
| SCHEMBL1203698 | 0.86 | DRD2 (1.00) | DRD2DRD1HTR1ATHDRD3 | |
| SCHEMBL10754712 | 0.86 | DRD2 (1.00) | DRD2DRD1HTR1ATHDRD3 | |
| Hydrochloric Acid SCHEMBL10752801 | 0.85 | DRD2 (0.98) | DRD2DRD1HTR1ATHDRD3 | |
| SCHEMBL1345058 | 0.83 | DRD2 (0.82) | DRD2DRD1HTR1ATHDRD3 | |
| SCHEMBL1345853 | 0.83 | DRD2 (0.82) | DRD2DRD1HTR1ATHDRD3 | |
| SCHEMBL1345068 | 0.81 | DRD2 (0.71) | DRD2DRD1HTR1ATHDRD3 | |
| SCHEMBL1345070 | 0.81 | DRD2 (0.71) | DRD2DRD1HTR1ATHDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10081600-B2 | 2-alkoxy-11-hydroxyaporphine derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2018-09-25 | — | — | US | disclosed |
| US-20170166531-A1 | 2-ALKOXY-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION | 2017-06-15 | — | — | US | disclosed |
| US-9517279-B2 | 2-alkoxy-11-hydroxyaporphine derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2016-12-13 | — | — | US | disclosed |
| US-20130209362-A1 | 2-ALKOXY-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2013-08-15 | — | — | US | disclosed |
| WO-2011130530-A1 | 2-ALKOXY-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2011-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10081600-B2 | 2-alkoxy-11-hydroxyaporphine derivatives and uses thereof | HTR5A, HTR2C, HTR3A | DRD2 11/4885DRD1 25/4885HTR1A 7/4885 |
| US-20130209362-A1 | 2-ALKOXY-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | HTR5A, HTR2C, HTR3A | DRD2 11/4885DRD1 25/4885HTR1A 7/4885 |
| US-20170166531-A1 | 2-ALKOXY-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | HTR5A, HTR2C, HTR3A | DRD2 11/4885DRD1 25/4885HTR1A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.