Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.71 |
| ▸ | HTR1A | P08908 | 4/20 | 0.71 |
| ▸ | TH | P07101 | 4/20 | 0.71 |
| ▸ | DRD1 | P21728 | 4/20 | 0.71 |
| ▸ | DRD3 | P35462 | 3/20 | 0.71 |
| ▸ | HTR2A | P28223 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MTOR | P42345 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | DRD5 | P21918 | 1/20 | 0.57 |
| ▸ | RGS12 | O14924 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1345070 | 1.00 | DRD2 (0.71) | DRD2HTR1ATHDRD1DRD3 | |
| SCHEMBL5549850 | 0.85 | DRD2 (0.52) | DRD2HTR1ATHDRD1DRD3 | |
| SCHEMBL1345853 | 0.85 | DRD2 (0.82) | DRD2HTR1ATHDRD1DRD3 | |
| SCHEMBL1345058 | 0.85 | DRD2 (0.82) | DRD2HTR1ATHDRD1DRD3 | |
| SCHEMBL1204059 | 0.84 | DRD1 (0.78) | DRD2HTR1ATHDRD1DRD3 | |
| SCHEMBL1204057 | 0.84 | DRD1 (0.78) | DRD2HTR1ATHDRD1DRD3 | |
| SCHEMBL1203699 | 0.83 | DRD2 (1.00) | DRD2HTR1ATHDRD1DRD3 | |
| SCHEMBL10754712 | 0.83 | DRD2 (1.00) | DRD2HTR1ATHDRD1DRD3 | |
| SCHEMBL1203698 | 0.83 | DRD2 (1.00) | DRD2HTR1ATHDRD1DRD3 | |
| SCHEMBL1347709 | 0.82 | ALDH1A1 (0.81) | DRD2HTR1ATHDRD1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063060-B2 | R(−)-11-hydroxyaporphine derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100081651-A1 | R(-)-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2010-04-01 | — | — | US | disclosed |
| US-7648995-B2 | R(—)-11-hydroxyaporphine derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2010-01-19 | — | — | US | disclosed |
| US-20060040900-A1 | R(-)-11-hydroxyaporphine derivatives and uses thereof | MCLEAN HOSPITAL CORPORATION, THE | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040900-A1 | R(-)-11-hydroxyaporphine derivatives and uses thereof | SNCA, HTR5A, PARK7 | DRD2 23/4885HTR1A 5/4885TH 329/4885 |
| US-20100081651-A1 | R(-)-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | SNCA, HTR5A, HTR3A | DRD2 23/4885HTR1A 5/4885TH 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.