Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12841887 | 0.85 | KDM4E (0.42) | MAPK1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL12841778 | 0.80 | MEN1 (0.58) | MAPK1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL18055562 | 0.80 | KDM4E (0.43) | MAPK1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL12841863 | 0.80 | KDM4E (0.51) | MAPK1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL3908276 | 0.79 | ALDH1A1 (0.44) | SMN1; SMN2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL23758044 | 0.77 | L3MBTL1 (0.51) | MAPK1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL11326931 | 0.69 | MAPK8 (0.51) | KMT2AKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL24855244 | 0.69 | NOS3 (0.36) | KDM4ENOS3NOS2 | |
| SCHEMBL12842064 | 0.69 | KDM4E (0.43) | MAPK1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL12841853 | 0.68 | KMT2A (0.48) | SMN1; SMN2KMT2AKDM4EALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159470-A1 | INHIBITORS OF NICOTINAMIDE N-METHYLTRANSFERASE, COMPOSITIONS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159470-A1 | INHIBITORS OF NICOTINAMIDE N-METHYLTRANSFERASE, COMPOSITIONS AND USES THEREOF | NNMT, NNT, NAMPT | MAPK1 2945/4885SMN1; SMN2 1143/4885MEN1 1075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.