Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25589178 | 0.84 | MAPT (0.42) | L3MBTL1KDM4ESMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL25587172 | 0.84 | ADORA3 (0.39) | L3MBTL1ADORA3ADORA2AADORA1KDM4E | |
| SCHEMBL25587168 | 0.77 | RAB9A (0.42) | L3MBTL1KDM4ECYP1A2CYP3A4CYP2C19 | |
| SCHEMBL25587173 | 0.76 | ALDH1A1 (0.47) | L3MBTL1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL24417654 | 0.73 | HTR2C (0.40) | L3MBTL1ADORA3ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL16867127 | 0.72 | L3MBTL1 (0.41) | L3MBTL1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL17458934 | 0.71 | L3MBTL1 (0.58) | L3MBTL1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL24015544 | 0.71 | L3MBTL1 (0.58) | L3MBTL1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL25587171 | 0.71 | RECQL (0.34) | KDM4ESMN1; SMN2ALDH1A1NPC1HTT | |
| SCHEMBL19170328 | 0.71 | L3MBTL1 (0.54) | L3MBTL1ADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174538-A1 | Tricyclic heterocycles | MERCK PATENT GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
| US-20230174538-A1 | Tricyclic heterocycles | MERCK PATENT GMBH (DE) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174538-A1 | Tricyclic heterocycles | YAP1, TEAD1, TERF2IP | L3MBTL1 1076/4885ADORA3 4848/4885ADORA2A 4676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.