Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGLRA1GLRBKCNK10KCNK18KCNK2KCNK3KCNK9
The experimentally established mechanism targets of Halothane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Halothane SCHEMBL443681 | 1.00 | — | — | |
| Halothane SCHEMBL337605 | 1.00 | — | — | |
| Halothane SCHEMBL1612295 | 1.00 | HSD17B10 (1.00) | — | |
| Halothane SCHEMBL1295253 | 0.96 | — | — | |
| Halothane SCHEMBL5961792 | 0.96 | HSD17B10 (0.92) | — | |
| Halothane SCHEMBL15475924 | 0.92 | — | — | |
| Halothane SCHEMBL6289622 | 0.92 | — | — | |
| Halothane SCHEMBL8902191 | 0.89 | HSD17B10 (0.79) | — | |
| Halothane SCHEMBL10725043 | 0.89 | — | — | |
| Halothane SCHEMBL9138026 | 0.80 | ALDH1A1 (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 29216 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260132404-A1 | MODIFIED OLIGONUCLEOTIDES AND DOUBLE-STRANDED RNAS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2026-05-14 | — | — | US | claimed |
| EP-4741492-A2 | NECROSIS INHIBITOR | Linkgevity Limited (GB) | 2026-05-13 | — | — | EP | claimed |
| EP-4719552-A1 | INDUCTION OF GENERAL ANESTHESIA IN ADULTS UNDERGOING ELECTIVE SURGERY | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2026-04-08 | — | — | EP | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| EP-4157407-B1 | INHALER DEVICE FOR INHALABLE LIQUIDS | MEDICAL DEVELOPMENTS INTERNATIONAL LTD (AU) | 2026-03-25 | — | — | EP | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-4698258-A1 | LOW INTERNAL RESISTANCE POLYMER PARTITIONED ANESTHETIC VAPORIZER SYSTEM AND METHOD | Rheos Medical Corp. (US) | 2026-02-25 | — | — | EP | claimed |
| US-20260048034-A1 | COMPOSITIONS AND METHODS FOR ENHANCING THE EFFICACY OF DICARBOXYLIC ACID ESTERS, AND USES THEREOF | NEW FRONTIER LABS LLC (US) | 2026-02-19 | — | — | US | claimed |
| EP-4696307-A1 | COMPOSITIONS AND METHODS FOR ENHANCING THE EFFICACY OF DICARBOXYLIC ACID ESTERS, AND USES THEREOF | New Frontier Labs, LLC (US) | 2026-02-18 | — | — | EP | claimed |
| EP-4651926-A1 | DEVICES, SYSTEMS, AND METHODS FOR ADMINISTERING HYDROGEN GAS | H2 Water Technologies Ltd (CA) | 2025-11-26 | — | — | EP | claimed |
| EP-0027005-A1 | A method of electrochemical sensing and a sensor for oxygen, halothane and nitrous oxide | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1981-04-15 | — | — | EP | claimed |
| US-4257860-A | Deuterium enrichment by selective photoinduced dissociation of a multihalogenated organic compound | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 1981-03-24 | — | — | US | claimed |
| US-4233842-A | Apparatus for measurement of expiration fluids | UNIVERSITY OF UTAH (US) | 1980-11-18 | — | — | US | claimed |
| US-4222967-A | Process for preparing bromine- and fluorine-containing halogenated hydrocarbons | KALI-CHEMIE AG (DE) | 1980-09-16 | — | — | US | claimed |
| US-4168308-A | Composition for enhancing the administration of pharmacologically active agents | APOTEKSVARUCENTRALEN VITRUM AB (SE) | 1979-09-18 | — | — | US | claimed |
| US-4091043-A | FLUORINATING 1,1,1-TRICHLOROETHANE WITH HYDROGEN FLUORIDE, ANTIMONY PENTACHLORIDE CATALYST | DAIKIN KOGYO CO., LTD. (JA) | 1978-05-23 | — | — | US | claimed |
| US-4053604-A | 3-HYDROXY-3-ISOPROPYL-2,3,4,4A,8,9,13B,14-OCTAHYDRO-1H -BENZO(6,7)CYCLOPENTA(1,2,3-DE)PYRIDO(2,1-A)ISOQUINOLIN-3-OL | AYERST, MCKENNA & HARRISON LIMITED (CA) | 1977-10-11 | — | — | US | claimed |
| US-4025630-A | Anesthesia methods using benzopyrans and esters thereof as pre-anesthesia medication | ABBOTT LABORATORIES (US) | 1977-05-24 | — | — | US | claimed |
| US-4015599-A | Anesthetic delivery system | ROHM AND HAAS COMPANY (US) | 1977-04-05 | — | — | US | claimed |
| US-3996302-A | Process for purifying 1,1,1-trifluoro-2-chloro-2-bromoethane | DYNAMIT NOBEL AKTIENGESELLSCHAFT (DT) | 1976-12-07 | — | — | US | claimed |